Natural Course of Perihemorrhagic Edema After Intracerebral Hemorrhage
Natural Course of Perihemorrhagic Edema After Intracerebral Hemorrhage
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DOI：
10.1161/strokeaha.111.618611
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发表时间：
2011-09-01
期刊：
影响因子：
8.3
通讯作者：
Bardutzky, Juergen
中科院分区：
文献类型：
--
作者：
Staykov, Dimitre;Wagner, Ingrid;Bardutzky, Juergen
背景和目的--关于脑出血(ICH)后出血周水肿(PHE)的时间进程，人们知之甚少。我们的目的是在一个大规模的回顾性脑出血队列中调查脑溢血的病程及其与住院死亡率的关系。方法：本研究纳入2006-2009年间在我所收治的幕上脑出血患者，这些患者在保守治疗过程中至少接受了3次CT扫描。使用基于阈值的半自动体积算法评估第1、2、3、4至6、7至11、12至16、17至21和22天的Phe。对住院时间、呼吸机、脑室外引流治疗和住院死亡率进行图表回顾。结果：219名年龄69.9+/-10.5岁的深部或叶部脑出血患者纳入研究。平均脑出血量为35.7±31.5毫升。平均绝对Phe体积在第7~11天由最初的32.6+/-29.9毫升增加至63.7+/-46.7毫升，以后各时间点无明显变化。ICH体积与Phe绝对体积显著相关(Rho=0.8，P
Background and Purpose-There is only limited knowledge on the time course of perihemorrhagic edema (PHE) after intracerebral hemorrhage (ICH). We aimed to investigate the chronological PHE course and its relation to in-hospital mortality in a large retrospective ICH cohort.Methods-Patients with supratentorial ICH treated at our institution between 2006 and 2009, who had received at least 3 CT scans in the course of conservative treatment, were included in the present analysis. PHE at Days 1, 2, 3, 4 to 6, 7 to 11, 12 to 16, 17 to 21, and >22 was assessed using a threshold based semiautomatic volumetric algorithm. A chart review was performed to achieve data on duration of stay, ventilation, treatment with external ventricular drains, and in-hospital mortality.Results-Two hundred nineteen patients aged 69.9 +/- 10.5 years with deep (n = 103) or lobar (n = 116) ICH were included in the study. Mean ICH volume was 35.7 +/- 31.5 mL. Mean absolute PHE volume significantly increased from initially 32.6 +/- 29.9 mL to 63.7 +/- 46.7 mL at Days 7 to 11. No significant changes were observed at later time points. ICH volume was strongly correlated with absolute PHE volume (rho=0.8, P