Nardochinoids A-C, Three Dimeric Sesquiterpenoids with Specific Fused-Ring Skeletons from Nardostachys chinensis
Nardochinoids A-C, Three Dimeric Sesquiterpenoids with Specific Fused-Ring Skeletons from Nardostachys chinensis
复制标题
甘松类化合物 A-C，具有来自甘松的特定稠环骨架的三种二聚倍半萜类化合物
DOI：
10.1021/acs.orglett.8b02511
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发表时间：
2018-09-21
期刊：
影响因子：
5.2
通讯作者：
Yao, Xin-Sheng
中科院分区：
文献类型：
--
作者：
Shen, Xiu-Yu;Qin, Da-Peng;Yao, Xin-Sheng
从赤竹中分离到三个罕见的倍半萜类二聚体nardochinoids A-C（1-3）。化合物1具有罕见的3,8-二氧杂环[7.2.1.0(1,6)]十二烷-11- 1环体系，化合物2是第一个含氮的去甲多辛烷-马里斯托烷倍半萜缀合物，化合物3是第一个去甲多辛烷和nardosin烷倍半萜二聚体的例子。用核磁共振波谱法和x射线单晶衍射分析对其结构进行了表征。化合物3具有明显的抗炎活性。
Three unusual sesquiterpenoid dimers, nardochinoids A-C (1-3), were isolated from Nardostachys chinensis Batal. Comyound 1 features a rare fused 3,8-dioxatricyclo [7.2.1.0(1,6)]dodecane-11-one ring system, compound 2 is the first nitrogen-containing nornardosinane-aristolane sesquiterpene conjugate, and compound 3 represents the first example of the dimer of a nornardosinane and a nardosinane sesquiterpene. Their structures were characterized by NMR spectroscopic methods and X-ray single-crystal diffraction analysis. Compound 3 showed significant anti-inflammatory activities.