Closing the loop: the adicol experience.
Closing the loop: the adicol experience.
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DOI：
10.1089/152091504774197990
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发表时间：
2004-06-01
影响因子：
5.4
通讯作者：
Pieber, Thomas R
中科院分区：
文献类型：
--
作者：
Hovorka, Roman;Chassin, Ludovic J;Pieber, Thomas R
ADICOL项目的目标是开发一种持续测量和控制1型糖尿病受试者血糖浓度的治疗系统。ADICOL的体外人工胰腺的模块化概念包括一个微创的皮下葡萄糖系统，一个掌上电脑和一个皮下注射胰岛素的胰岛素泵(D-Tron，Disetronic，Burgdorf，瑞士)。本文描述了ADICOL活动的一个子集，重点是开发用于半闭环控制的血糖控制器、电子测试环境、临床测试和系统集成。采用增量法对模型预测血糖控制器进行了实验评估。在可行性研究之后，进行了日益复杂的疗效研究。ADICOL项目证明了在禁食和喂养条件下使用可穿戴的模块化体外人工胰腺进行半闭环血糖控制的可行性。
The objective of the project Advanced Insulin Infusion using a Control Loop (ADICOL) was to develop a treatment system that continuously measures and controls the glucose concentration in subjects with type 1 diabetes. The modular concept of the ADICOL's extracorporeal artificial pancreas consisted of a minimally invasive subcutaneous glucose system, a handheld PocketPC computer, and an insulin pump (D-Tron, Disetronic, Burgdorf, Switzerland) delivering subcutaneously insulin lispro. The present paper describes a subset of ADICOL activities focusing on the development of a glucose controller for semi-closed-loop control, an in silico testing environment, clinical testing, and system integration. An incremental approach was adopted to evaluate experimentally a model predictive glucose controller. A feasibility study was followed by efficacy studies of increasing complexity. The ADICOL project demonstrated feasibility of a semi-closed-loop glucose control during fasting and fed conditions with a wearable, modular extracorporeal artificial pancreas.