Peripheral nerve regeneration: An opinion on channels, scaffolds and anisotropy
Peripheral nerve regeneration: An opinion on channels, scaffolds and anisotropy
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DOI：
10.1016/j.biomaterials.2006.02.030
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发表时间：
2006-07-01
期刊：
影响因子：
14
通讯作者：
Bellamkonda, RV
中科院分区：
文献类型：
--
作者：
Bellamkonda, RV
周围神经再生是一个重大的临床挑战，目前使用自体移植物修复长的周围神经缺损的技术水平并不令人满意。在这篇手稿中，分析框架，决定移植物（自体移植物或生物材料为基础的移植物）的命运进行了讨论。还概述了参数和变量，可能被操纵，以提高周围神经再生设计的支架的功效。使用适当的动物模型和结果的措施，在评估生物材料为基础的支架或其他工程结构适用于桥接周围神经间隙的重要性是突出。(c)2006爱思唯尔有限公司保留所有权利。
Peripheral nerve regeneration presents a significant clinical challenge and the Current state of the art using autografts to repair long peripheral nerve gaps is unsatisfactory. In this manuscript, the analytical framework that determines the fate of grafts (autografts or biomaterial-based grafts) is discussed. Also outlined are parameters and variables that might be manipulated to enhance the efficacy of scaffolds designed for peripheral nerve regeneration. The importance Of using appropriate animal models and outcome measures in evaluating biomaterials-based scaffolds or other engineered constructs suitability for bridging peripheral nerve gaps is highlighted. (c) 2006 Elsevier Ltd. All rights reserved.