Liver, bone marrow, pancreas and pituitary gland iron overload in young and adult thalassemic patients: a T2 relaxometry study
Liver, bone marrow, pancreas and pituitary gland iron overload in young and adult thalassemic patients: a T2 relaxometry study
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DOI：
10.1007/s00330-007-0683-1
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发表时间：
2007-12-01
影响因子：
5.9
通讯作者：
Efremidis, Stavros C.
中科院分区：
文献类型：
--
作者：
Argyropoulou, Maria I.;Kiortsis, Dimitrios N.;Efremidis, Stavros C.
研究了37例重型β地中海贫血患者，包括14例青少年（15.2 ± 3.0岁）和23例成人（26.4 ± 6.9岁）。在1.5特斯拉磁共振（MR）成像仪中，使用多回波自旋回波序列（TR/TE 2，000/20、40、60、80、100、120、140、160 ms）测量肝脏、骨髓、胰腺和垂体的T2弛豫时间（T2）。在自旋回波序列（TR/TE，500/20 ms）的中线矢状扫描中评价了前列腺高度。青少年垂体T2（59.4 +/- 15 ms）高于成人（45.3 +/- 10.4 ms），P < 0.05。青少年胰腺的T2（43.6 +/- 10.3 ms）低于成人（54.4 +/- 10.4 ms）。肝脏和骨髓的T2在组间无差异。肝脏、胰腺、垂体和骨髓中T2无明显相关性。血清铁蛋白与肝、胰、骨髓T2无明显相关性。垂体T2与垂体高度（青少年：R=0.63，成人：R=0.62，P < 0.05）和血清铁蛋白（青少年：R=-0.60，成人：R=-0.50，P < 0.05）呈显著相关。总之，T2评价的铁过载具有器官特异性。青春期后，与年龄相关的T2变化主要与垂体铁质沉着症和胰腺脂肪变性有关。随着铁质沉着症的进展，血小板的大小逐渐减小。
Thirty-seven patients with beta-thalassemia major, including 14 adolescents (15.2 +/- 3.0 years) and 23 adults (26.4 +/- 6.9 years), were studied. T2 relaxation time (T2) of the liver, bone marrow, pancreas and pituitary gland was measured in a 1.5-Tesla magnetic resonance (MR) imager, using a multiecho spin-echo sequence (TR/TE 2,000/20, 40, 60, 80, 100, 120, 140, 160 ms). Pituitary gland height was evaluated in a midline sagittal scan of a spin-echo sequence (TR/TE, 500/20 ms). The T2 of the pituitary gland was higher in adolescents (59.4 +/- 15 ms) than in adults (45.3 +/- 10.4 ms), P < 0.05. The T2 of the pancreas was lower in adolescents (43.6 +/- 10.3 ms) than in adults (54.4 +/- 10.4 ms). No difference among groups was found in the T2 of the liver and bone marrow. There was no significant correlation of the T2 among the liver, pancreas, pituitary gland and bone marrow. There was no significant correlation between serum ferritin and T2 of the liver, pancreas and bone marrow. Pituitary T2 showed a significant correlation with pituitary gland height (adolescents: R=0.63, adults: R=0.62, P < 0.05) and serum ferritin (adolescents: R=-0.60, adults: R=-0.50, P < 0.05). In conclusion, iron overload evaluated by T2 is organ specific. After adolescence, age-related T2 changes are predominantly associated with pituitary siderosis and fatty degeneration of the pancreas. Pituitary size decreases with progressing siderosis.