Rapidly inducible, genetically targeted inactivation of neural and synaptic activity in vivo.
Rapidly inducible, genetically targeted inactivation of neural and synaptic activity in vivo.
复制标题
体内神经和突触活动的快速诱导、基因靶向失活。
DOI：
10.1016/j.conb.2007.10.002
复制
发表时间：
2007
影响因子：
5.7
通讯作者：
Karpova,AllaY
中科院分区：
文献类型：
--
作者：
Tervo,Dougal;Karpova,AllaY
Inducible and reversible perturbation of the activity of selected neurons in vivo is critical to understanding the dynamics of brain circuits. Several genetically encoded systems for rapid inducible neuronal silencing have been developed in the past few years offering an arsenal of tools for in vivo experiments. Some systems are based on ion-channels or pumps, others on G protein coupled receptors, and yet others on modified presynaptic proteins. Inducers range from light to small molecules to peptides. This diversity results in differences in the various parameters that may determine the applicability of each tool to a particular biological question. Although further development would be beneficial, the current silencing tool kit already provides the ability to make specific perturbations of circuit function in behaving animals.
