Risk factors for gastroschisis: A case-control study in a Brazilian population
Risk factors for gastroschisis: A case-control study in a Brazilian population
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DOI：
10.1002/ijgo.13135
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发表时间：
2020-03-31
影响因子：
3.8
通讯作者：
Brizot, Maria L.
中科院分区：
文献类型：
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作者：
Freitas, Amanda B.;Centofanti, Sandra F.;Brizot, Maria L.
目的探讨与胎儿腹裂相关的危险因素。方法将2013年7月1日至2015年7月31日在圣保罗大学医学院附属医院妇产科胎儿内科就诊的孕妇分为腹裂组和对照组，其中腹裂孕妇怀有腹裂胎儿，对照组胎儿正常。对照组的患者在研究开始时在母亲年龄、先孕体重指数和孕周方面进行匹配。在怀孕期间进行了面对面的访谈，以获得人口统计、医学和社会特征；接触物质；妊娠史；慢性病、尿路感染(UTIs)、流感和发烧的存在；以及在最后一个月经期间到怀孕早期的一个月内发生压力事件的情况。结果在171名纳入研究的妇女中，57人被分配到腹裂组，114人被分配给对照组。腹裂与母体尿路感染(P=0.011)、吸烟(P=0.001)、饮酒(P
Objective To evaluate risk factors associated with fetal gastroschisis.Methods As a secondary aim of a larger case-control study, pregnant women attending the Fetal Medicine Unit at the Department of Obstetrics and Gynecology at Hospital das Clinicas, Sao Paulo University Medical School between July 1, 2013, and July 31, 2015, were allocated into either the gastroschisis group, where the woman was carrying a fetus with gastroschisis, or the control group, where the fetus was normal. Patients in the control group were matched at study entry for maternal age, preconception body mass index and weeks of gestation. In-person interviews were conducted during pregnancy to obtain data on demographic, medical, and social characteristics; exposure to substances; pregnancy history; the presence of chronic disease, urinary tract infections (UTIs), influenza, and fever; and the occurrence of stress events between the month before the last menstrual period and the first trimester of pregnancy.Results Of 171 women included in the study, 57 were allocated to the gastroschisis group and 114 to the control group. There were significant associations between gastroschisis and maternal UTI (P=0.011), tobacco use (P=0.001), alcohol consumption (P