Muller Glial Cell-Provided Cellular Light Guidance through the Vital Guinea-Pig Retina
Muller Glial Cell-Provided Cellular Light Guidance through the Vital Guinea-Pig Retina
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DOI：
10.1016/j.bpj.2011.09.062
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发表时间：
2011-12-07
影响因子：
3.4
通讯作者：
Reichenbach, Andreas
中科院分区：
文献类型：
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作者：
Agte, Silke;Junek, Stephan;Reichenbach, Andreas
在脊椎动物的眼睛中，图像被投射到倒置的视网膜上，光线在到达感光细胞的过程中通过视网膜的所有层。该组织内的光散射会损害视力。我们发现，活视网膜中的放射状胶质（Muller）细胞最大限度地减少了视网膜内的光散射，并保留了照射到单个Muller细胞端足的光束的直径。因此，光以高强度到达单个光感受器。这导致一个优化的信号/噪声比，这增加了视觉灵敏度和对比度。此外，我们发现穆勒细胞和锥体（负责急性视觉）之间的比例大约是1。这表明，高时空分辨率可以通过每个锥通过其单独的穆勒细胞光导接收其部分图像来实现。
In vertebrate eyes, images are projected onto an inverted retina where light passes all retinal layers on its way to the photoreceptor cells. Light scattering within this tissue should impair vision. We show that radial glial (Muller) cells in the living retina minimize intraretinal light scatter and conserve the diameter of a beam that hits a single Muller cell endfoot. Thus, light arrives at individual photoreceptors with high intensity. This leads to an optimized signal/noise ratio, which increases visual sensitivity and contrast. Moreover, we show that the ratio between Muller cells and cones-responsible for acute vision-is roughly 1. This suggests that high spatiotemporal resolution may be achieved by each cone receiving its part of the image via its individual Muller cell-light guide.