NEURAL REGULATION OF INSULIN-SECRETION IN DOG
NEURAL REGULATION OF INSULIN-SECRETION IN DOG
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DOI：
10.1172/jci107168
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发表时间：
1973-01-01
影响因子：
15.9
通讯作者：
POSTERNAK, J
中科院分区：
文献类型：
--
作者：
PORTE, D;GIRARDIER, L;POSTERNAK, J
在测定胰十二指肠静脉血流量和胰岛素浓度的条件下，研究了刺激混合自主神经对狗胰腺的影响。刺激导致胰岛素输出增加，但先前服用阿托品可以阻断胰岛素输出。刺激引起的血流量减少与刺激速率成比例。在 40 次刺激/秒时，在 1 分钟时发现最大效果，尽管继续施加刺激，但逐渐返回基线。阿托品化对血流变化没有影响。在阿托品化动物中，通过以 40 个周期/秒同时刺激胰神经，胰岛素对 0.1 g/kg 葡萄糖的反应平均降低 40%。这些研究将该制剂建立为可重复的模型，用于直接检查自主神经对内分泌胰腺功能的影响。由此得出结论，狗内分泌胰腺的神经供应足以通过交感神经的激活来抑制胰岛素分泌，并通过副交感神经的激活来刺激胰岛素分泌。
The effects of stimulation of the mixed autonomic nerve to the dog pancreas has been studied under conditions in which both pancreaticoduodenal vein blood flow and insulin concentration were determined. Stimulation resulted in increased insulin output, which was blocked by prior administration of atropine. Blood flow was reduced by stimulation in proportion to the rate of stimulation. At 40 stimuli/s a maximum effect was found at 1 min with a gradual return toward base line despite continued application of the stimulus. Atropinization had no effect on blood flow changes. Insulin responses to 0.1 g/kg glucose were reduced on the average 40% by simultaneous stimulation of the pancreatic nerve at 40 cycles/s in atropinized animals. These studies establish this preparation as a reproducible model for the direct examination of autonomic influences on endocrine pancreatic function. From them it is concluded that the nerve supply to the endocrine pancreas of the dog is sufficient to inhibit insulin secretion by activation of the sympathetic nerves and to stimulate insulin secretion by activation of the parasympathetic nerves.