The prevalence and clinical characteristics of Charles Bonnet Syndrome in Danish patients with neovascular age-related macular degeneration
The prevalence and clinical characteristics of Charles Bonnet Syndrome in Danish patients with neovascular age-related macular degeneration
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DOI：
10.1111/j.1755-3768.2010.02051.x
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发表时间：
2012-08-01
影响因子：
3.4
通讯作者：
Sorensen, Torben L.
中科院分区：
文献类型：
--
作者：
Singh, Amardeep;Sorensen, Torben L.
。目的：调查Charles Bonnet综合征（CBS）在一组丹麦新生血管性年龄相关性黄斑变性（AMD）患者中的患病率和临床特征，并研究CBS是否与特定的视网膜形态有关。方法：连续300例新血管性AMD患者在接受可变系列雷尼单抗治疗后参加评估会诊，积极询问他们是否有CBS症状。如果他们的回答是肯定的，一份详细的口头问卷调查症状的细节。进行了详细的光学相干层析成像和自身荧光。对随机选择的等量无CBS患者和有CBS患者的视网膜形态学进行比较。结果：300例患者中有25例（8.3%）出现可归因于CBS的幻觉。以自身荧光增加的总面积衡量的中位病变大小，CBS组（中位14.2 mm2）与非CBS组（中位16.2 mm2）无显著差异；然而，与没有CBS的患者（中位数为0.3 mm2）相比，CBS患者的地理萎缩面积（中位数为2 mm2）明显更大（p = 0.002）。结论：CBS在新生血管性AMD患者中并不罕见，CBS的症状可能与更大面积的地理萎缩有关。
. Purpose: To investigate the prevalence and clinical characteristics of the Charles Bonnet Syndrome (CBS) in a group of Danish patients with neovascular age-related macular degeneration (AMD) and to study whether CBS is associated with a specific retinal morphology. Methods: Three-hundred consecutive patients with neovascular AMD attending assessment consultations following variable series of ranibizumab therapy were actively asked whether they had symptoms of CBS. If they responded positively, a detailed questionnaire was orally administered to inquire into the details of the symptoms. Detailed optical coherence tomography and autofluorescence was performed. A comparison was made between retinal morphology of a randomly selected equal number of patients without CBS to patients with CBS. Results: Twenty-five (8.3%) patients of 300 had hallucinations attributable to CBS. The median lesion size measured as total area with increased autofluorescence in the CBS group (median 14.2 mm2) was not significantly different from the non-CBS group (median 16.2 mm2); however, the patients with CBS had significantly larger areas of geographic atrophy (median 2 mm2) compared to patients without CBS (median 0.3 mm2) (p = 0.002). Conclusion: CBS is not uncommon in an unselected population with neovascular AMD, and symptoms of CBS may be associated with larger areas of geographic atrophy.