A convenient synthesis of 1,4-disubstituted imidazoles
A convenient synthesis of 1,4-disubstituted imidazoles
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DOI：
10.1016/j.tetlet.2004.05.011
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发表时间：
2004-07-05
影响因子：
1.8
通讯作者：
Lovely, CJ
中科院分区：
文献类型：
--
作者：
He, Y;Chen, YZ;Lovely, CJ
通过使用各种咪唑保护基的所有烷基化-异构化序列，开发了一种有效的4-烷基-、4-碘代、4-乙烯基咪唑区域选择性保护方法。最初形成的4/5-烷基-、4/5-碘代和4/5-乙烯基咪唑的混合物在用少量RX处理DMF溶液并在75 ℃下加热时异构化为相应的4-异构体。(C)2004爱思唯尔有限公司保留所有权利。
An efficient method for the regioselective protection of 4-alkyl-, 4-iodo, 4-vinylimidazoles has been developed via all alkylation-isomerization sequence with various imidazole-protecting groups. The initially formed mixture of 4/5-alkyl-, 4/5-iodo, and 4/5-vinylimidazoles are isomerized to the corresponding 4-isomers on treatment of a DMF solution with a small amount of RX and heating at 75degreesC. (C) 2004 Elsevier Ltd. All rights reserved.