Murisolin: A New Cytotoxic Mono-tetrahydrofuran-g-lactone from Annona muricata
Murisolin: A New Cytotoxic Mono-tetrahydrofuran-g-lactone from Annona muricata
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Murisolin：来自番荔枝的一种新的细胞毒性单四氢呋喃-g-内酯
DOI：
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发表时间：
1990
期刊：
影响因子：
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通讯作者：
D. Cortes
中科院分区：
文献类型：
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作者：
S. H. Myint;A. Laurens;R. Hocquemiller;A. Cavé;D. Davoust;D. Cortes
以细胞毒活性为指标，从番荔枝种子中分离得到一种新的活性成分。Murisolin，1是仅具有三个羟基的单四氢呋喃-γ-内酯乙酸配基的第一个实例。其结构通过质谱和2D均相和异相相关核磁共振谱表征。用核磁共振氢谱法比较了三醋酸菌索林和一些双四氢呋喃乙酸酯的光谱，确定了其六个手性中心中四个的相对立体化学
Using cytotoxicity as a bioassay guide led to the isolation of a new active acetogenin from the seed of Annona muricata. Murisolin, 1 is the first example of a mono-tetrahydrofuran-γ-lactone acetogenin with only three hydroxyl groups. Its structure was characterised by mass spectrometry and 2D homonuclear and heteronuclear correlations nmr spectroscopy. The relative stereochemistry of four of its six chiral centers was established bh 1 H-nmr comparative spectral studies between the murisolin triacetate and some bistetrahydrofuran acetogenin acetates