Particle transport across a channel via an oscillating potential.
Particle transport across a channel via an oscillating potential.
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粒子通过振荡电势穿过通道传输。
DOI：
10.1103/physreve.96.052401
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
S. Pagliara
中科院分区：
文献类型：
--
作者：
Yizhou Tan;Jannes Gladrow;U. Keyser;L. Dagdug;S. Pagliara
膜蛋白转运蛋白根据交替进入机制在膜的细胞外侧和胞质侧之间交替其底物结合位点。受到大自然设计的这种有趣机制的启发，我们研究了通过与能量井耦合的通道的粒子传输，能量井在通道的两个入口之间振荡其位置。我们通过调整振荡频率来优化粒子在通道中的传输。在最佳振荡频率下，通过通道的易位速率比通过通道的自由扩散高一百倍。我们的研究结果揭示了时间依赖性电势对粒子跨通道传输的影响，并将与膜传输和微流体应用相关。
Membrane protein transporters alternate their substrate-binding sites between the extracellular and cytosolic side of the membrane according to the alternating access mechanism. Inspired by this intriguing mechanism devised by nature, we study particle transport through a channel coupled with an energy well that oscillates its position between the two entrances of the channel. We optimize particle transport across the channel by adjusting the oscillation frequency. At the optimal oscillation frequency, the translocation rate through the channel is a hundred times higher with respect to free diffusion across the channel. Our findings reveal the effect of time-dependent potentials on particle transport across a channel and will be relevant for membrane transport and microfluidics application.