APOE Alleles in Parkinson Disease and Their Relationship to Cognitive Decline: A Population-based, Longitudinal Study
APOE Alleles in Parkinson Disease and Their Relationship to Cognitive Decline: A Population-based, Longitudinal Study
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DOI：
10.1177/0891988709332945
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发表时间：
2009-09-01
影响因子：
2.6
通讯作者：
Alves, Guido
中科院分区：
文献类型：
--
作者：
Kurz, Martin Wilhelm;Dekomien, Gabriele;Alves, Guido
载脂蛋白E基因等位基因与多种心血管和神经退行性疾病有关。关于载脂蛋白E等位基因与帕金森病和帕金森病痴呆症之间的关联，有相互矛盾的报道。为探讨载脂蛋白E等位基因在帕金森病和帕金森病痴呆中的作用，我们对95例帕金森病患者进行了载脂蛋白E基因分型，并与73例健康对照组进行了比较。此外，在纵向随访的帕金森病患者中，多因素分析和生存分析表明，等位基因类型与痴呆的发生和进展以及从帕金森病到痴呆的时间相关。载脂蛋白E-epsilon-4-epsilon-4基因在帕金森病患者中的频率(7.4%)明显高于健康对照组(1.4%；P=0.03)。未发现载脂蛋白E基因与痴呆症的发生和进展或痴呆的时间之间存在显著的相关性。有必要对更大的帕金森病样本进行更多的研究。
Apolipoprotein E gene alleles have been linked to various cardiovascular and neurodegenerative disorders. There have been conflicting reports of associations between Apolipoprotein E alleles and Parkinson disease and Parkinson disease dementia. To investigate the role of Apolipoprotein E alleles in Parkinson disease and Parkinson disease dementia, we have determined Apolipoprotein E genotypes in a group of patients with Parkinson disease (n = 95) and compared them with those of healthy control participants (n = 73). Additionally, in 64 longitudinally followed patients with Parkinson disease, the allele types were correlated to development and progression of dementia and to time from onset of Parkinson disease to dementia using multivariate and survival analyses. The Apolipoprotein E epsilon 4 epsilon 4 genotype was more common in patients with Parkinson disease (7.4%) than in healthy controls (1.4%; P = .03). No significant associations between the Apolipoprotein E genotype and development and progression of dementia or time to dementia were found. More studies with larger Parkinson disease samples are warranted.