Hormonal and splanchnic hemodynamic alterations following hepatic resection.
Hormonal and splanchnic hemodynamic alterations following hepatic resection.
复制标题
肝切除术后激素和内脏血流动力学的改变。
DOI：
10.1006/jsre.1993.1106
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Sitzmann,JV
中科院分区：
文献类型：
--
作者：
Wu,Y;Campbell,KA;Sitzmann,JV
Reported hemodynamic changes after partial hepatectomy (PH) include elevations in portal blood flow and pressure (Ppv). The etiology of these changes is unknown. We studied degree of portosystemic shunt (PSS), splanchnic artery blood flow and resistance (Qspl,Rspl) as well as prostacyclin (PGI2), glucagon, and insulin response in rats undergoing 75% hepatectomy. The results showed that following an immediate threefold rise in portal PGI2, a hemody namically significant PSS developed at 48 hr. The PGI2changes paralleled the increase in portal flow (Qpv), pressure (Ppv), PSS, and the decrease inRspl. Glucagon levels also rose immediately postresection, but fell to normal prior to resolution of both PSS and hyperemia. There was no significant change in insulin or glucose levels after resection. This implies a relationship between PSS and the release of a prostanoid effectingQpv,Qspl, andRsplwhich relates to, and possibly mediates, the hemodynamic changes following liver resection. We conclude that PH is a model of acute PHT, and that the altered splanchnic hemodynamics could relate to hepatic regeneration.
