Propofol and midazolam inhibit gastric emptying and gastrointestinal transit in mice
Propofol and midazolam inhibit gastric emptying and gastrointestinal transit in mice
复制标题
DOI：
10.1213/01.ane.0000130852.53082.d5
复制
发表时间：
2004-10-01
影响因子：
5.7
通讯作者：
Shingu, K
中科院分区：
文献类型：
--
作者：
Inada, T;Asai, T;Shingu, K
我们研究了异丙酚和咪达唑仑对小鼠胃排空和胃肠转运的影响。异丙酚或咪达唑仑腹腔注射10min后，向胃内注入含荧光微球的生理盐水0.2mL。30min后切除胃肠道，用流式细胞仪测定胃肠道内荧光微球的数量，计算胃排空和胃肠转运。在产生轻度镇静的剂量下(小鼠站立在2 S以内)，两种药物对胃排空的抑制程度相似(异丙酚：P<；0.001与对照组；95%可信区间[CI]，差异为4.9%-20.2%；咪达唑仑：P<；0.001与对照组；95%CI：差异，7.8%-14.7%)。咪达唑仑，但不是异丙酚，延迟了胃肠道传输(P<；0.001)。在镇静程度较深的大剂量(无翻正反射)时，两药均显著抑制胃排空(异丙酚：P<；0.001；95%CI：31.4%~61.2%；咪达唑仑：P<；0.001；95%CI：30.8%~61.1%)和胃肠通过(P<；0.001)。
We studied the effect of propofol and midazolam on gastric emptying and gastrointestinal transit in mice. Ten minutes after intraperitoneal injection of propofol or midazolam, 0.2 mL of saline containing fluorescent microbeads was infused into the stomach. Thirty minutes later, the gastrointestinal tract was excised, and gastric emptying and gastrointestinal transit were calculated by measuring the quantity of fluorescent microbeads in the gastrointestinal tract by using a flow cytometer. At a dose that produced a light level of sedation (mice righted themselves within 2 s), both drugs significantly, but weakly, inhibited gastric emptying to a similar degree (propofol: P < 0.001 versus control value; 95% confidence interval [CI] for difference, 4.9%-20.2%; midazolam: P < 0.001 versus control value; 95% CI for difference, 7.8%-14.7%). Midazolam, but not propofol, delayed gastrointestinal transit (P < 0.001). At a larger dose that produced a deeper level of sedation (absence of righting reflex >10 s), both drugs significantly inhibited gastric emptying (propofol: P < 0.001; 95% CI for difference, 31.4%-61.2%; midazolam: P < 0.001; 95% CI for difference, 30.8%-61.1%) and gastrointestinal transit (P < 0.001 for both drugs).