Adaptogenic effect of Bacopa monniera (Brahmi)
Adaptogenic effect of Bacopa monniera (Brahmi)
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DOI：
10.1016/s0091-3057(03)00156-4
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发表时间：
2003-07-01
影响因子：
3.6
通讯作者：
Singh, HK
中科院分区：
文献类型：
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作者：
Rai, D;Bhatia, G;Singh, HK
由于压力与许多疾病有关，因此对来自植物的有效抗压力剂（adaptogen）的研究越来越重要。本文报道了假马齿苋标准提取物对大鼠急性和慢性应激模型的适应性研究。以西洋参根粉为标准品。雄性SD大鼠，体重180-200 g，暴露于制动应激150 min，AS组仅一次，CS组连续7天，用B喂养。monniera或人参根粉，每天在AS中持续3天，在CS中持续7天，每次暴露应激前45分钟。应激后立即处死大鼠，取血，分离血浆进行生化测定。解剖肾上腺、脾脏和胸腺以测定器官重量，解剖胃以测定溃疡评分。AS暴露显著增加溃疡指数、肾上腺重量、血糖、丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）和肌酸激酶（CK），但显著降低脾脏重量。用B预处理。monniera 40 mg/kg po显著降低AS诱导的溃疡指数、肾上腺重量、血糖、AST和CK的增加。80 mg/kg po剂量显著逆转了AS诱导的肾上腺重量、脾脏重量、血糖、ALT和AST变化。人参根粉100 mg/kg po可显著逆转AS引起的脾重、血浆ALT、AST和CK的变化。CS暴露导致溃疡指数、肾上腺重量、血浆AST和CK显著增加，胸腺和脾脏重量、血浆甘油三酯和胆固醇显著降低。低剂量B预处理。40 mg/kg的monniera提取物仅显著逆转溃疡指数和血浆AST的变化，而用更高剂量的预处理显著逆转CS诱导的溃疡指数、肾上腺重量、CK和AST的变化。人参根粉显著逆转CS引起的溃疡指数、肾上腺重量、CK和AST的增加。结果表明，标准化提取物B. monniera具有有效的适应原活性。(C)2003年爱思唯尔公司All rights reserved.
As stress is linked to many diseases, research on an effective antistress agent (adaptogen) from plants has gained importance. We report the investigations on the adaptogenic property of a standardized extract of Bacopa monniera against acute (AS) and chronic stress (CS) models in rats. Panax root powder (Panax quinquefolium) was taken as a standard. Male SD rats, weighing 180-200 g, exposed to immobilization stress for 150 min once only for AS and for seven consecutive days in CS, were fed with B. monniera or Panax root powder daily for 3 days in AS and for 7 days in CS, 45 min prior to each exposure of stress. Rats were sacrificed immediately after stress, the blood was collected, and the plasma was separated out for biochemical estimation. Adrenals, spleen, and thymus were dissected for organ weight and stomach for ulcer score. AS exposure significantly increased the ulcer index, adrenal gland weight, plasma glucose, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and creatine kinase (CK) but significantly decreased the spleen weight. Pretreatment with B. monniera at 40 mg/kg po significantly reduced the AS-induced increase in the ulcer index, adrenal gland weight, plasma glucose, AST, and CK. A dose of 80 mg/kg po significantly reversed the AS-induced changes in adrenal gland weight, spleen weight, plasma glucose, ALT, and AST. Panax root powder, 100 mg/kg po, significantly reversed the AS-induced changes in spleen weight, plasma ALT, AST, and CK. CS exposure resulted in a significant increase in the ulcer index, adrenal gland weight, plasma AST, and CK with a significant decrease in the thymus and spleen weight, plasma triglyceride, and cholesterol. Pretreatment with low dose of B. monniera extract at 40 mg/kg significantly reversed changes in ulcer index and plasma AST only, whereas the pretreatment with higher dose significantly reversed CS-induced changes in ulcer index, adrenal gland weight, CK, and AST. Panax root powder significantly reversed CS-induced increase in ulcer index, adrenal gland weight, CK, and AST. On the basis of our result, it is concluded that the standardized extract of B. monniera possesses a potent adaptogenic activity. (C) 2003 Elsevier Inc. All rights reserved.