Comparative studies on the metabolism of oestradiol in the brain, the pituitary and the liver of the rat.
Comparative studies on the metabolism of oestradiol in the brain, the pituitary and the liver of the rat.
复制标题
雌二醇在大鼠脑、垂体和肝脏代谢的比较研究。
DOI：
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发表时间：
1978
期刊：
影响因子：
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通讯作者：
R. Knuppen
中科院分区：
文献类型：
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作者：
P. Ball;M. Haupt;R. Knuppen
将放射性雌二醇与去卵巢大鼠下丘脑、垂体和肝脏匀浆及皮质、海马、下丘脑、垂体和肝脏切片共孵育。2-和4-取代雌激素是脑中的主要代谢物，并且以相同的比例被发现。在肝脏中，只有2-取代雌激素是主要代谢产物，而4-取代的雌激素具有次要的定量重要性。以湿重计，肝脏的2-羟基化能力约为大脑的50倍，而4-羟基化能力与大脑大致相同。只有轻微的差异，在2-和4-羟化能力的各个脑区进行了观察，虽然显然下丘脑和垂体更活跃的儿茶酚雌激素的形成比皮质和海马。
Radioactive oestradiol was incubated with homogenates of hypothalamus, pituitary and liver and slices of cortex, hippocampus, hypothalamus, pituitary and liver of ovariectomized rats. 2- and 4-substituted oestrogens were the main metabolites in the brain and were found in the same proportions. In the liver only the 2-substituted oestrogens were the main metabolites, while the 4-substituted ones were of minor quantitative importance. On the basis of wet weight the 2-hydroxylating capacity of the liver was approximately 50 fold greater than that of the brain and the 4-hydroxylating capacity about the same as that of the brain. Only slight differences in the 2- and 4-hydroxylating capacity of various brain areas were observed, although apparently the hypothalamus and the pituitary were more active in the formation of catecholestrogens than the cortex and the hippocampus.