Swept-Source Anatomic Optical Coherence Elastography of Porcine Trachea.
Swept-Source Anatomic Optical Coherence Elastography of Porcine Trachea.
复制标题
猪气管的扫描源解剖光学相干弹性成像。
DOI：
10.1117/12.2213186
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Oldenburg,AmyL
中科院分区：
文献类型：
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作者：
Bu,Ruofei;Price,Hillel;Mitran,Sorin;Zdanski,Carlton;Oldenburg,AmyL
定量内窥镜成像是评估上呼吸道阻塞的新技术的先锋。解剖光学相干断层扫描（aOCT）具有提供高分辨率和四维气道腔几何形状的潜力。通过将aOCT与压力测量相结合，可以执行光学相干弹性成像（OCE）以表征气道壁刚度。这可以帮助识别动态塌陷区域以及通知计算流体动力学建模以帮助手术决策。为此，在这里，我们报告的解剖光学相干断层扫描（aOCT）系统由波长扫描激光源供电。该系统采用外径为0.82 mm的光纤导管，通过市售柔性支气管镜的孔展开。进行螺旋扫描以测量气道几何形状并量化气道的横截面积（CSA）。我们报告了aOCT用于弹性成像的初步验证，其中aOCT衍生的CSA作为压力的函数获得，以估计气道壁顺应性。在乳胶橡胶管上进行的实验得到的柔度测量值为0.68±0.02 mm 2/cmH 2 O，在10至40 cmH 2 O的压力范围内R2=0.98。接下来，研究离体猪气管，得到从1.06±0.12至3.34±0.44 mm 2/cmH 2 O的测量顺应性（R2>0.81）。数据的线性证实了气道的弹性性质。顺应性值在与人类上呼吸道的先前测量相同的数量级内，这表明该系统能够在未来的人类研究中评估气道壁顺应性。
Quantitative endoscopic imaging is at the vanguard of novel techniques in the assessment upper airway obstruction. Anatomic optical coherence tomography (aOCT) has the potential to provide the geometry of the airway lumen with high-resolution and in 4 dimensions. By coupling aOCT with measurements of pressure, optical coherence elastography (OCE) can be performed to characterize airway wall stiffness. This can aid in identifying regions of dynamic collapse as well as informing computational fluid dynamics modeling to aid in surgical decision-making. Toward this end, here we report on an anatomic optical coherence tomography (aOCT) system powered by a wavelength-swept laser source. The system employs a fiber-optic catheter with outer diameter of 0.82 mm deployed via the bore of a commercial, flexible bronchoscope. Helical scans are performed to measure the airway geometry and to quantify the cross-sectional-area (CSA) of the airway. We report on a preliminary validation of aOCT for elastography, in which aOCT-derived CSA was obtained as a function of pressure to estimate airway wall compliance. Experiments performed on a Latex rubber tube resulted in a compliance measurement of 0.68±0.02 mm2/cmH2O, with R2=0.98 over the pressure range from 10 to 40 cmH2O. Next, ex vivo porcine trachea was studied, resulting in a measured compliance from 1.06±0.12 to 3.34±0.44 mm2/cmH2O, (R2>0.81). The linearity of the data confirms the elastic nature of the airway. The compliance values are within the same order-of-magnitude as previous measurements of human upper airways, suggesting that this system is capable of assessing airway wall compliance in future human studies.