No lengthening of life span in mice continuously exposed to gamma rays at very low dose rates
No lengthening of life span in mice continuously exposed to gamma rays at very low dose rates
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DOI：
10.1667/rr3042
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发表时间：
2003-09-01
影响因子：
3.4
通讯作者：
Sato, F
中科院分区：
文献类型：
--
作者：
Tanaka, S;Tanaka, IB;Sato, F
电离辐射持续照射的迟发效应对辐射设施工作人员和公众都是潜在的危害。最近，低剂量率和低剂量效应已成为一个严重的问题。用总共4 000只小鼠研究了长期受低剂量率辐射的后期生物效应，并以寿命为指标进行了测定。将2000只雄性和2000只雌性8周龄无特定病原体（SPF）B6 C3 F1小鼠随机分为4组（1组为未照射对照组，3组为照射组）。使用Cs-137伽马射线以21 mGy/天（-1）、1.1 mGy/天（-1）和0.05 mGy/天（-1）的剂量率进行辐照约400天，总剂量分别相当于8000 mGy、400 mGy和20 mGy。将所有小鼠保持在SPF条件下，直到它们自发死亡。经统计学分析，21 mGy日（-1）照射组雌雄小鼠的寿命（P < 0.0001）和1.1mGy日（-1）照射组雌性小鼠的寿命（P < 0.05）均明显短于对照组。我们的研究结果表明，没有证据表明，小鼠的寿命延长持续暴露在非常低的剂量率的伽马射线。(C)2003年，辐射研究协会。
Late effects of continuous exposure to ionizing radiation are potential hazards to-workers in radiation facilities as well as to the general public. Recently, low-dose-rate and low-dose effects have become a serious concern. Using a total of 4000 mice were studied the late,biological effects of chronic exposure to low-dose-rate radiation as assayed by life span. Two thousand male and 2000 female 8-week-old specific-pathogen-free (SPF) B6C3F1 mice were randomly divided into four groups (one nonirradiated control and three irradiated). Irradiation was carried out for approximately 400 days using Cs-137 gamma rays at dose rates of 21 mGy day(-1), 1.1 mGy day(-1) and 0.05 mGy day(-1) with total doses equivalent to 8000 mGy, 400 mGy and 20 mGy, respectively. All mice were kept under SPF conditions until they died spontaneously. Statistical analyses showed that the life spans of mice of both sexes irradiated with 21 mGy day(-1) (P < 0.0001) and of females irradiated with 1.1 mGy day(-1) (P < 0.05) were significantly shorter than those of the control group. Our results show no evidence of lengthened life span in mice continuously exposed to very low dose rates of gamma rays. (C) 2003 by Radiation Research Society.