Calcium, Amylase, and Flow Rate of Rat Parotid Saliva with Diverse Frequencies of Parasympathetic Nerve Stimulation 1
Calcium, Amylase, and Flow Rate of Rat Parotid Saliva with Diverse Frequencies of Parasympathetic Nerve Stimulation 1
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不同副交感神经刺激频率下大鼠腮腺唾液的钙、淀粉酶和流量 1
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发表时间：
1979
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通讯作者：
C. Schneyer
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作者：
C. Schneyer
当电刺激大鼠腮腺副交感神经节后纤维引起分泌时，唾液钙浓度随流速的增加而增加，但在频率为16 Hz时，钙浓度和流速均达到最大值。在最高流速下，钙的浓度是血清的3倍。在所有流速下，唾液的淀粉酶活性始终保持较低。因此，这些数据表明，虽然钙和淀粉酶一起分泌，但有些钙可能在没有淀粉酶的情况下分泌。由此推断，钙的浓缩机制也可能在腺泡水平，由于富含钙的前体液流经导管系统，在高流速下，导管细胞对钙的吸收很少，但随着接触时间的增加和流速的降低，更多的钙被重新吸收，导致最终唾液中的钙含量低。钙浓度的增加不太可能是由于导管细胞对水的再吸收，因为至少在灌注的主要颌下导管中，导管细胞是相对不透水的。目前的数据表明了这一解释，但需要对前体液的钙浓度进行微穿刺分析才能确定这一事实。不同类型的自主神经刺激下的流速差异不能用来评价唾液中钙浓度与流速的关系，只有当流速和钙浓度与特定类型的自主神经刺激进行比较时，这种比较才有意义。
Summary Calcium concentration of saliva, when electrical stimulation of the parasympathetic postganglionic fibers to rat parotid is used to evoke secretion, increases with increases in flow rate, but both calcium concentration and flow rate reach maximal levels at frequencies of 16 Hz. The concentration of calcium at highest flow rate is three times that of serum. Amylase activity of the saliva remains consistently low at all flow rates. Therefore, these data show that while calcium and amylase are secreted together, some calcium may be secreted without amylase. By inference it is also possible to suggest that the concentrating mechanism for calcium is at the acinar level, and that as the precursor fluid, rich in calcium, flows through the duct system, very little absorption of calcium by ductal cells occurs at high flow rates, but as contact time is increased with decreasing flow rate, more calcium is reabsorbed, resulting in a final saliva low in calcium. It is not likely that the increased calcium concentration is the result of reabsorption of water by ductal cells since in perfused main submaxillary duct at least, the duct cells are relatively impermeable to water. The present data suggest this interpretation, but micropuncture analysis of calcium concentration of the precursor fluid is required to establish this as a fact. Flow rate differences found with different kinds of autonomic stimulation cannot be used to assess relationships between calcium concentration and flow rate of saliva, and only when the flow rate and calcium concentration are compared with a particular kind of autonomic stimulation are such comparisons meaningful.