Territorial blueprint in the hippocampal system.
Territorial blueprint in the hippocampal system.
复制标题
海马系统的领地蓝图。
DOI：
10.1016/j.tics.2021.06.005
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发表时间：
2021
影响因子：
19.9
通讯作者：
Sirigu,Angela
中科院分区：
文献类型：
--
作者：
Wirth,Sylvia;Soumier,Amelie;Eliava,Marina;Derdikman,Dori;Wagner,Shlomo;Grinevich,Valery;Sirigu,Angela
当我们熟练地在熟悉的地方导航时，对距离和坐标的神经计算没有引起我们的注意。然而，我们清楚地感觉到空间被划分为具有社会意义的领土。“我的空间”和“你的空间”是我们大家都熟悉的区别。空间边界本质上是社会性的，因为它们根据等级和从属关系来管理个人获得空间公用事业的机会。大脑是如何将空间几何与社会领域结合在一起的？我们认为催产素(OT)在内嗅觉-海马区的作用支持这一过程。基于下丘脑神经肽在海马体系统中的功能作用，我们展示了OT诱导的可塑性如何偏向位置和网格细胞的几何编码，以代表社会领域。
As we skillfully navigate through familiar places, neural computations of distances and coordinates escape our attention. However, we perceive clearly the division of space into socially meaningful territories. ‘My space' versus ‘your space' is a distinction familiar to all of us. Spatial frontiers are social in nature since they regulate individuals' access to utilities in space depending on hierarchy and affiliation. How does the brain integrate spatial geometry with social territory? We propose that the action of oxytocin (OT) in the entorhinal–hippocampal regions supports this process. Grounded on the functional role of the hypothalamic neuropeptide in the hippocampal system, we show how OT-induced plasticity may bias the geometrical coding of place and grid cells to represent social territories.