Pathologic assessment of vasculopathies in pulmonary hypertension
Pathologic assessment of vasculopathies in pulmonary hypertension
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DOI：
10.1016/j.jacc.2004.02.033
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发表时间：
2004-06-16
影响因子：
24
通讯作者：
Tuder, RM
中科院分区：
文献类型：
--
作者：
Pietra, GG;Capron, F;Tuder, RM
肺动脉高压（Pulmonary arterial hypertension， PAH）包括多种病因不同但临床表现和功能紊乱相似的肺动脉高压。各种形式PAH的组织病理血管变化在质上相似，但在肺血管床各部分的病理变化的分布和流行程度上存在定量差异。肺血管对损伤反应的这些地形变化的记录可能对了解PAR各亚群的发病机制很重要。为了标准化PAH中肺血管病变的精确组织病理学记录，我们提出了一种组织病理学分类，该分类既包括受影响的肺血管的主要部分，也包括其他血管段可能共存的病理变化。(C) 2004年由美国心脏病学会基金会发布。
Pulmonary arterial hypertension (PAH) includes various forms of pulmonary hypertension of different etiology but similar clinical presentation and functional derangement. Histopathological vascular changes in all forms of PAH are qualitatively similar but with quantitative differences in the distribution and prevalence of pathological changes in various portions of the pulmonary vascular bed. The documentation of these topographic variations in the response of the pulmonary vasculature to injury may be important to understand the pathogenesis of the various subsets of PAR To standardize the precise histopathological documentation of the pulmonary vasculopathy in PAH we propose a histopathological classification that includes both the predominant segment of the pulmonary vasculature affected and the possible coexistence of pathological changes in other vascular segments. (C) 2004 by the American College of Cardiology Foundation.