Theileria Apicoplast as a Target for Chemotherapy
Theileria Apicoplast as a Target for Chemotherapy
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DOI：
10.1128/aac.00126-08
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发表时间：
2009-03-01
影响因子：
4.9
通讯作者：
Ralph, Stuart A.
中科院分区：
文献类型：
--
作者：
Lizundia, Regina;Werling, Dirk;Ralph, Stuart A.
它们的寄生虫在世界大部分地区造成严重的牛疾病和死亡。这些顶复合体寄生虫具有残余质体（顶质体），其代谢途径包括几种有希望的药物靶点。筛选了这些靶点的推定抑制剂，并确定了值得进一步表征的抗增殖化合物。
Theileria parasites cause severe bovine disease and death in a large part of the world. These apicomplexan parasites possess a relic plastid (apicoplast), whose metabolic pathways include several promising drug targets. Putative inhibitors of these targets were screened, and we identified antiproliferative compounds that merit further characterization.