THE IMMUNOHISTOCHEMICAL EVIDENCE OF AMYLOID DIFFUSE DEPOSITS AS A PATHOLOGICAL HALLMARK IN ALZHEIMERS-DISEASE
THE IMMUNOHISTOCHEMICAL EVIDENCE OF AMYLOID DIFFUSE DEPOSITS AS A PATHOLOGICAL HALLMARK IN ALZHEIMERS-DISEASE
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DOI：
10.1093/geronj/46.6.b209
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发表时间：
1991-11-01
期刊：
影响因子：
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通讯作者：
MAZZUCA, M
中科院分区：
文献类型：
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作者：
BEHROUZ, N;DEFOSSEZ, A;MAZZUCA, M
我们进行了免疫细胞化学研究的大脑皮层的情况下，阿尔茨海默病和老年非痴呆症的控制，使用高碘酸预处理和多克隆β-蛋白抗体。 除老年斑（SP）和淀粉样血管病（AA）外，β蛋白抗体还检测到整个皮质层存在带状沉积物。 此外，在皮质灰质和白色物质中观察到具有弥漫性和无定形特征的大斑块样浸润，这些沉积物通常与毛细血管有关。 我们的研究结果表明，丰富的这些病变，这是只检测到这种免疫染色程序在阿尔茨海默氏症皮层，可能是阿尔茨海默氏症的特点。
We performed an immunocytochemical study of cerebral cortex from cases of Alzheimer's disease and from aged nondemented controls, using periodic acid pretreatment and polyclonal beta-protein antibodies. In addition to senile plaques (SP) and amyloid angiopathy (AA), the beta-protein antibodies detected band-like deposits present throughout the cortical layers. Moreover, large plaque-like infiltrations with diffuse and amorphous characteristics were observed in the cortical gray and white matter, and these deposits were often associated with capillaries. Our results suggest that an abundance of these lesions, which were detected only with this immunostaining procedure in Alzheimer cortex, may be characteristic of Alzheimer's disease.