The Effect of Subcutaneous Fat on Electrical Impedance Myography: Electrode Configuration and Multi-Frequency Analyses.
The Effect of Subcutaneous Fat on Electrical Impedance Myography: Electrode Configuration and Multi-Frequency Analyses.
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DOI：
10.1371/journal.pone.0156154
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Zhou P
中科院分区：
文献类型：
--
作者：
Li L;Li X;Hu H;Shin H;Zhou P
本研究探讨皮下脂肪层(SFL)厚度对局部电阻抗肌图(EIM)的影响，以及不同距离和方向的电流电极对EIM输出的影响。23名健康受试者使用手持电极阵列对其二头肌进行多频局部EIM。EIM测量被记录在三种不同的配置下：宽(或外)纵向配置6.8 cm、窄(或内)纵向配置4.5 cm和窄横向配置4.5 cm。超声测量SFL厚度。计算了三个EIM变量(电阻、电抗和相位)和SFL厚度的决定系数(R2)。对于纵向构型，与窄距离相比，宽距离可以减少皮下脂肪的影响，但三个EIM参数仍然存在显著的相关性。然而，在横向构型中，单层厚度与电抗之间没有显著的相关性(R2=0.0294，p=0.434)。研究发现，采用50 kHz/100 kHz的相位比能够帮助降低所有三种配置的SFL厚度的相关性。研究结果表明，适当选择电流电极的距离、方向和多频相位比可以减小皮下脂肪对EIM的影响。这些设置应在未来的临床研究中使用手持局部阵列进行EIM评估。
This study investigates the impact of the subcutaneous fat layer (SFL) thickness on localized electrical impedance myography (EIM), as well as the effects of different current electrodes, varying in distance and direction, on EIM output. Twenty-three healthy subjects underwent localized multi-frequency EIM on their biceps brachii muscles with a hand-held electrode array. The EIM measurements were recorded under three different configurations: wide (or outer) longitudinal configuration 6.8 cm, narrow (or inner) longitudinal configuration 4.5 cm, and narrow transverse configuration 4.5 cm. Ultrasound was applied to measure the SFL thickness. Coefficients of determination (R2) of three EIM variables (resistance, reactance, and phase) and SFL thickness were calculated. For the longitudinal configuration, the wide distance could reduce the effects of the subcutaneous fat when compared with the narrow distance, but a significant correlation still remained for all three EIM parameters. However, there was no significant correlation between SFL thickness and reactance in the transverse configuration (R2 = 0.0294, p = 0.434). Utilizing a ratio of 50kHz/100kHz phase was found to be able to help reduce the correlation with SFL thickness for all the three configurations. The findings indicate that the appropriate selection of the current electrode distance, direction and the multi-frequency phase ratio can reduce the impact of subcutaneous fat on EIM. These settings should be evaluated for future clinical studies using hand-held localized arrays to perform EIM.