Focal loss of anterior horn cells in the cervical cord in motor neuron disease.
Focal loss of anterior horn cells in the cervical cord in motor neuron disease.
复制标题
运动神经元疾病中颈髓前角细胞的局灶性丢失。
DOI：
10.1093/brain/109.5.939
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
K. Swettenham
中科院分区：
文献类型：
--
作者：
M. Swash;M. Leader;A. Brown;K. Swettenham
在对人类脊髓 C8 段前角细胞分布的三维研究中，我们已经识别出运动神经元分组的外侧和内侧区域，但无法识别这些分组中类似于早期研究人员描述的解剖柱的神经元亚组。这一观察结果并没有否定这些前角细胞池内功能分组的概念。在对运动神经元疾病患者尸检时获得的脊髓同一节段进行的研究中，发现了运动神经元局灶性丧失的区域，但不同断面水平的严重程度或分布没有一致。这些发现意味着不同运动神经元池对疾病的抵抗力不同。
In a three-dimensional study of the distribution of anterior horn cells in the C8 segment of the human spinal cord we have recognized lateral and medial zones of motor neuron groupings, but have not been able to recognize subgroups of neurons within these groupings resembling the anatomical columns described by earlier investigators. This observation does not invalidate the concept of functional groupings within these anterior horn cell pools. In studies of the same segment in cords obtained at autopsy from patients with motor neuron disease, zones of focal loss of motor neurons were identified, without consistent severity or distribution at different sectional levels. These findings imply varying resistance to the disease in different pools of motor neurons.