IGFBP-5 induces epithelial and fibroblast responses consistent with the fibrotic response.
IGFBP-5 induces epithelial and fibroblast responses consistent with the fibrotic response.
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IGFBP-5 诱导上皮细胞和成纤维细胞反应，与纤维化反应一致。
DOI：
10.1042/bst0370882
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发表时间：
2009
影响因子：
3.9
通讯作者：
Sureshbabu A
中科院分区：
文献类型：
--
作者：
Sureshbabu A
纤维化涉及成纤维细胞的激活、胶原蛋白和纤连蛋白的产生增加以及转分化为收缩性肌成纤维细胞。这一过程类似于伤口愈合的各个方面，但仍未得到解决，特别是在肾脏、肺和肝脏中表现出来时，可能危及生命。其原因在很大程度上是未知的，但最近的建议，重复性微损伤导致上皮细胞修复的最终失败，由于复制衰老正在获得青睐。这与纤维化疾病在中年的发病是一致的。由于上皮损伤通常涉及失血，与纤维化反应相关的炎症反应已被认为是治疗靶点。然而，事实证明，这在很大程度上是不成功的，现在的重点转向这一过程中的早期事件。这些包括EMT（上皮-间充质转化）和成纤维细胞活化在没有炎症。TGFβ1（transforming growth factor-β1）诱导EMT和成纤维细胞活化，被认为是主要的促纤维化因子。最近，IGFBP-5 [IGF（胰岛素样生长因子）结合蛋白-5]也被证明对TGFβ1有类似的作用，并且与衰老过程密切相关。它还刺激外周血单核细胞的迁移，使其参与炎症反应。在本文中，我们研究了IGFBP-5在纤维化中作用的证据，并强调了其与其他基质蛋白和生长因子的结构关系，这些蛋白和生长因子也与组织重塑有关。
Fibrosis involves activation of fibroblasts, increased production of collagen and fibronectin and transdifferentiation into contractile myofibroblasts. The process resembles aspects of wound-healing but remains unresolved and can be life-threatening when manifest in the kidneys, lungs and liver, in particular. The causes are largely unknown, but recent suggestions that repetitive micro-injury results in the eventual failure of epithelial cell repair due to replicative senescence are gaining favour. This is consistent with the onset of fibrotic diseases in middle age. Because epithelial injury often involves blood loss, inflammatory responses associated with the fibrotic response have been considered as therapeutic targets. However, this has proved largely unsuccessful and focus is now switching to earlier events in the process. These include EMT (epithelial–mesenchymal transition) and fibroblast activation in the absence of inflammation. TGFβ1 (transforming growth factor-β1) induces both EMT and fibroblast activation and is considered to be a major pro-fibrotic factor. Recently, IGFBP-5 [IGF (insulin-like growth factor)-binding protein-5] has also been shown to induce similar effects on TGFβ1, and is strongly implicated in the process of senescence. It also stimulates migration of peripheral blood mononuclear cells, implicating it in the inflammatory response. In this paper, we examine the evidence for a role of IGFBP-5 in fibrosis and highlight its structural relationship with other matrix proteins and growth factors also implicated in tissue remodelling.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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通讯作者：
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影响因子：
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作者：
Pilewski, JM;Liu, LX;Feghali-Bostwick, CA
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DOI：
--
发表时间：
1994
期刊：
Biochemistry and cell biology = Biochimie et biologie cellulaire
影响因子：
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作者：
R. Guenette;M. Tenniswood
通讯作者：
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影响因子：
4.8
作者：
Schedlich, LJ;Young, TF;Baxter, RC
通讯作者：
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