Receptor for advanced glycation end products -: soluble form and gene polymorphisms in chronic haemodialysis patients
Receptor for advanced glycation end products -: soluble form and gene polymorphisms in chronic haemodialysis patients
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DOI：
10.1093/ndt/gfm050
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发表时间：
2007-07-01
影响因子：
6.1
通讯作者：
Zima, Tomas
中科院分区：
文献类型：
--
作者：
Kalousova, Marta;Jachymova, Marie;Zima, Tomas
背景晚期糖基化终末产物受体（receptor for advanced glycation end products，RECEPTOR）参与血管和炎症性疾病的发病机制。可溶性β-淀粉酶（saponin，saponin）在生理上抑制由β-淀粉酶介导的病理作用。我们的目的是研究血液透析（HD）患者的sxD和sxD基因多态性。共有261例稳定的HD患者入组研究，并前瞻性随访30个月。在研究开始时，确定了皮肤炎症和营养参数。在214例HD患者的亚组中确定了α多态性。并以100名健康人为对照组。在HD患者中，与健康对照组相比，sIgA升高（3427 +/- 1508 vs 1758 +/- 637 pg/ml，P < 0.001）。与残余多尿量呈负相关（r =-0.193，P < 0.05），与急性期反应物纤维蛋白原（r =-0.174，P < 0.05）、类粘蛋白（r =-0.135，P < 0.05）及白细胞计数呈负相关（r =-0.158，P < 0.05）。另一方面，它与糖尿病、心血管疾病、营养状况和死亡率的存在无关。最高水平的sbR被发现在-429 CC和2184 GG多态性的基因。内源性分泌型雌二醇（esophagus，esophagus）与sophagus呈显著正相关（r = 0.88，P < 0.001）。我们的结论是，在HD患者中，由于肾功能下降，血清白蛋白增加，这是血清白蛋白水平的一个非常强的决定因素，并与炎症呈负相关。最高的sRAGE水平受到遗传影响。在我们的研究中，血肌酐水平与HD患者的死亡率无关。
Background. The receptor for advanced glycation end products (RAGE) is involved in the pathogenesis of vascular and inflammatory diseases. The pathological effects mediated via RAGE are physiologically inhibited by soluble RAGE (sRAGE). Our aim was to study sRAGE and RAGE gene polymorphisms in haemodialysis (HD) patients.Methods. A total of 261 stable HD patients were enrolled in the study and prospectively followed up for 30 months. At the begining of the study, sRAGE inflammatory and nutritional parameters were determined. RAGE polymorphisms were determined in a subgroup of 214 HD patients. A group of 100 healthy controls was used for comparison.Results. In HD patients, sRAGE is elevated in comparison with healthy controls (3427 +/- 1508 vs 1758 +/- 637 pg/ml, P < 0.001). It correlates negatively with residual diuresis (r = -0.193, P < 0.05), with the acute phase reactants fibrinogen (r = -0.174, P < 0.05) and orosomucoid (r = -0.135, P < 0.05) and with the leucocyte count (r = -0.158, P < 0.05). On the other hand, it is not related to the presence of diabetes mellitus, cardiovascular disease, nutritional status and mortality. The highest sRAGE levels are found in -429 CC and 2184 GG polymorphisms of the RAGE gene. The same results as for sRAGE were obtained for endogenous secretory RAGE (esRAGE), which correlated significantly with sRAGE (r = 0.88, P < 0.001).Conclusion. We conclude that in HD patients, sRAGE is increased due to decreased renal function, which is a very strong determinant of sRAGE levels, and is inversely related to inflammation. The highest sRAGE levels are influenced genetically. In our study, sRAGE levels were not related to mortality of HD patients.