Salivary levels of hyaluronic acid in female patients with dry mouth compared with age-matched controls: a pilot study
Salivary levels of hyaluronic acid in female patients with dry mouth compared with age-matched controls: a pilot study
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DOI：
10.2220/biomedres.30.63
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发表时间：
2009-02-01
影响因子：
1.2
通讯作者：
Takehara, Tadamichi
中科院分区：
文献类型：
--
作者：
Higuchi, Yasushi;Ansai, Toshihiro;Takehara, Tadamichi
关于唾液中透明质酸（HA）水平与口干状态之间的关联知之甚少。本研究的目的是评估女性口干患者（自觉口干和唾液分泌不足）唾液中HA的水平，并将其与年龄匹配的对照组进行比较。我们研究了46名女性，并根据感觉到的口干和唾液流速将她们分为两组，以及无症状的对照组。测定未刺激的全唾液中的HA浓度，发现组间存在显著差异。统计学相关性较强的患者（自觉口干，normosalivation）管理的致干药物，而在该组中的HA水平显着低于对照组转换为绝对量的唾液每分钟。在本研究的局限性，口干患者的唾液中HA水平较低，这可能是作为一个标记的局部干燥或口腔粘膜润滑。
Little is known regarding the association between the level of hyaluronic acid (HA) in saliva and dry Mouth status. The aim of this study was to evaluate the salivary levels of HA in female patients with dry mouth (perceived xerostomia and hyposalivation) and compare them with age-matched controls. We Studied 46 females, and classified them into two groups based on perceived xerostomia and salivary flow rate, as well as a control group Without symptoms. HA concentrations in unstimulated whole saliva were determined and a significant difference was found between the groups. The statistical association was stronger in patients (perceived xerostomia, normosalivation) administrated xerogenic drugs, while the HA levels in that group were significantly lower than those in the controls when converted to absolute amount of saliva per min. Within the limitations of the present study, patients with dry mouth had lower HA levels in saliva, which may serve as a marker of local dryness or oral mucosa lubrication.