Age-related changes in slow wave sleep and REM sleep and relationship with growth hormone and cortisol levels in healthy men
Age-related changes in slow wave sleep and REM sleep and relationship with growth hormone and cortisol levels in healthy men
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DOI：
10.1001/jama.284.7.861
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发表时间：
2000-08-16
影响因子：
120.7
通讯作者：
Plat, L
中科院分区：
文献类型：
--
作者：
Van Cauter, E;Leproult, R;Plat, L
在年轻人中，睡眠影响生长激素（GH）和皮质醇的调节。老年人睡眠质量下降与生长激素和皮质醇调节的年龄相关性变化之间的关系尚不清楚。目的确定睡眠时间和质量的年龄相关性变化的时间顺序（睡眠阶段）设计和设置数据来自1985年至1999年在4对象：149名健康男性。年龄16 - 83岁，平均（SD）体重指数为24.1（2.3）kg/m（2），无睡眠主诉或内分泌、精神病史，主要结果测量血浆GH和皮质醇水平的24小时曲线和多导睡眠记录。在成年早期（16-25岁），这一比例为1.3%（1.3%），在中年（36-50岁）为3.4%（1.0%），并被较浅的睡眠（第1和第2阶段）所取代，而没有显著增加睡眠碎片或减少快速眼动（REM）睡眠。从中年到晚年（71-83岁）的过渡并没有进一步显著减少慢波睡眠，但清醒时间每10年增加28分钟，代价是轻度非REM睡眠减少（每10年-24分钟; P
Context In young adults, sleep affects the regulation of growth hormone (GH) and cortisol. The relationship between decreased sleep quality in older adults and age-related changes in the regulation of GH and cortisol is unknown.Objective To determine the chronology of age-related changes in sleep duration and quality (sleep stages) in healthy men and whether concomitant alterations occur in GH and cortisol levels.Design and Setting Data combined from a series of studies conducted between 1985 and 1999 at 4 laboratories.Subjects A total of 149 healthy men. aged 16 to 83 years, with a mean (SD) body mass index of 24.1 (2.3) kg/m(2), without sleep complaints or histories of endocrine, psychiatric, or sleep disorders.Main Outcome Measures Twenty-four-hour profiles of plasma GH and cortisol levels and polygraphic sleep recordings.Results The mean (SEM) percentage of deep slow wave sleep decreased from 18.9% (1.3%) during early adulthood (age 16-25 years) to 3.4% (1.0%) during midlife (age 36-50 years) and was replaced by lighter sleep (stages 1 and 2) without significant increases in sleep fragmentation or decreases in rapid eye movement (REM) sleep. The transition from midlife to late life (age 71-83 years) involved no further significant decrease in slow wave sleep but an increase in time awake of 28 minutes per decade at the expense of decreases in both light non-REM sleep (-24 minutes per decade; P