Evolution of the Calcium-Based Intracellular Signaling System.
Evolution of the Calcium-Based Intracellular Signaling System.
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DOI：
10.1093/gbe/evw139
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发表时间：
2016-07-14
影响因子：
3.3
通讯作者：
Gough J
中科院分区：
文献类型：
--
作者：
Marchadier E;Oates ME;Fang H;Donoghue PC;Hetherington AM;Gough J
为了将我们对分子进化的理解从一组经过充分研究的基因提升到细胞水平，我们必须考虑整个系统。在这里，我们揭示了一个重要的细胞内信号系统的演变。钙信号工具包由不同的多结构域蛋白组成，这些蛋白经历了复制、重组、序列差异和选择。考虑到现存生物和祖先的工具包中的蛋白质库，进化的图景与其他系统的图景截然不同。在真核生物中，该库在丰度和多样性方面的增加速度远远高于一般的基因组扩增。我们描述了如何钙为基础的细胞内信号的演变不仅在速度上，但在性质上不同，以及如何与植物和动物的差异。
To progress our understanding of molecular evolution from a collection of well-studied genes toward the level of the cell, we must consider whole systems. Here, we reveal the evolution of an important intracellular signaling system. The calcium-signaling toolkit is made up of different multidomain proteins that have undergone duplication, recombination, sequence divergence, and selection. The picture of evolution, considering the repertoire of proteins in the toolkit of both extant organisms and ancestors, is radically different from that of other systems. In eukaryotes, the repertoire increased in both abundance and diversity at a far greater rate than general genomic expansion. We describe how calcium-based intracellular signaling evolution differs not only in rate but in nature, and how this correlates with the disparity of plants and animals.