Mitochondrial Control of Innate Immunity and Inflammation.
Mitochondrial Control of Innate Immunity and Inflammation.
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DOI：
10.4110/in.2017.17.2.77
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发表时间：
2017-04
期刊：
影响因子：
6
通讯作者：
Jo EK
中科院分区：
文献类型：
--
作者：
Jin HS;Suh HW;Kim SJ;Jo EK
线粒体是参与能量生产的关键细胞器，是细胞的新陈代谢中心。最近的发现强调了线粒体作为调节先天免疫和炎症反应的关键细胞内信号平台的新角色。几种线粒体蛋白和线粒体活性氧物种已经成为协调对病原体的先天性免疫反应和破坏配体的核心角色。本文就线粒体在调节先天免疫和炎症反应中的作用作一综述。我们对自噬、线粒体和炎性小体激活之间的关系的最新进展也进行了简要讨论。全面了解线粒体在Toll样受体介导的先天免疫反应和NLRP3炎症体复合体激活中的作用，将有助于开发治疗各种感染性、炎症性和自身免疫性疾病的新疗法。
Mitochondria are key organelles involved in energy production, functioning as the metabolic hubs of cells. Recent findings emphasize the emerging role of the mitochondrion as a key intracellular signaling platform regulating innate immune and inflammatory responses. Several mitochondrial proteins and mitochondrial reactive oxygen species have emerged as central players orchestrating the innate immune responses to pathogens and damaging ligands. This review explores our current understanding of the roles played by mitochondria in regulation of innate immunity and inflammatory responses. Recent advances in our understanding of the relationship between autophagy, mitochondria, and inflammasome activation are also briefly discussed. A comprehensive understanding of mitochondrial role in toll-like receptor-mediated innate immune responses and NLRP3 inflammasome complex activation, will facilitate development of novel therapeutics to treat various infectious, inflammatory, and autoimmune disorders.