Ten-year incidence and risk factors of bone fractures in a cohort of treated HIV1-infected adults
Ten-year incidence and risk factors of bone fractures in a cohort of treated HIV1-infected adults
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DOI：
10.1097/qad.0b013e3283292195
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发表时间：
2009-05-15
期刊：
影响因子：
3.8
通讯作者：
Raffi, Francois
中科院分区：
文献类型：
--
作者：
Collin, Fideline;Duval, Xavier;Raffi, Francois
在1997-1999年以来接受抗逆转录病毒联合治疗的ANRS CO8 APROCO-COPILOTE队列患者中，骨折的发生率密度为3.3 / 1000患者年[95%置信区间(CI) = 2.0-4.6]。过量饮酒患者的发生率高2.9倍（95% CI = 1.3-6.5），合并丙型肝炎病毒（HCV）感染患者的发生率高3.6倍（95% CI = 1.6-8.1）。应建议对HCV/ hiv合并感染患者进行特殊监测，并积极促进戒酒，以预防骨折。
In the ANRS CO8 APROCO-COPILOTE cohort of patients treated with combination antiretroviral therapy since 1997-1999, the incidence density of bone firactures was 3.3 for 1000 patient-years [95% confidence interval (CI) = 2.0-4.6]. The rate was 2.9-fold (95% CI = 1.3-6.5) higher among patients with excessive alcohol consumption and 3.6-fold (95% CI = 1.6-8.1) higher in those with hepatitis C virus (HCV) coinfection. Specific monitoring of HCV/HIV-coinfected patients and active promotion of alcohol cessation should be recommended for the prevention of bone fractures.