Cumulative Effects of Prior Concussion and Primary Sport Participation on Brain Morphometry in Collegiate Athletes: A Study From the NCAA-DoD CARE Consortium
Cumulative Effects of Prior Concussion and Primary Sport Participation on Brain Morphometry in Collegiate Athletes: A Study From the NCAA-DoD CARE Consortium
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DOI：
10.3389/fneur.2020.00673
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发表时间：
2020-07-28
影响因子：
3.4
通讯作者：
Rowson, Steven
中科院分区：
文献类型：
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作者：
Brett, Benjamin L.;Bobholz, Samuel A.;Rowson, Steven
先前的研究报道了脑结构（脑形态测量学）的长期差异与累积性脑震荡和接触性运动的参与有关。越来越多的证据表明，先前的脑震荡和参与接触性运动对大脑形态测量学的类似影响可能存在于年轻的活跃运动员群体中。我们研究了活跃的大学接触性运动和非接触性运动运动员的皮层下和皮层结构与先前脑震荡与初级运动参与的关系。接触性运动运动员（CS；N= 190）和匹配的非接触性运动运动员（NCS；N= 95）完成了基线临床测试，并在6个月的时间内参加了多达四次连续的神经成像会议。使用FreeSurfer获得皮层下和皮层结构指标。线性混合效应（LME）模型检验了主要运动参与年限和先前脑震荡（0,1 +）对脑结构和基线临床变量的影响。两组均有脑震荡病史的运动员报告的基线脑震荡和心理症状均显著增加（均< 0.05）。初级体育参与年数与丘脑体积之间的关系在CS和NCS之间存在差异（p= 0.015），这是由于初级体育参与年数与丘脑体积之间存在显著的负相关（p= 0.007）。仅限于CS的其他分析显示，主要运动参与年数与背纹状体体积之间的关系被脑震荡史缓和（p= 0.042）。最后，有脑震荡史的CS比没有脑震荡史的CS的海马体积更大（p= 0.015）。接触性运动的年数和先前的脑震荡与年轻成年、活跃的大学运动员皮质下体积的差异有关，这与先前关于退役、主要有症状的接触性运动运动员的文献一致。需要对这些运动员进行纵向随访研究，以确定当前研究结果的临床意义。
Prior studies have reported long-term differences in brain structure (brain morphometry) as being associated with cumulative concussion and contact sport participation. There is emerging evidence to suggest that similar effects of prior concussion and contact sport participation on brain morphometry may be present in younger cohorts of active athletes. We investigated the relationship between prior concussion and primary sport participation with subcortical and cortical structures in active collegiate contact sport and non-contact sport athletes. Contact sport athletes (CS;N= 190) and matched non-contact sport athletes (NCS;N= 95) completed baseline clinical testing and participated in up to four serial neuroimaging sessions across a 6-months period. Subcortical and cortical structural metrics were derived using FreeSurfer. Linear mixed-effects (LME) models examined the effects of years of primary sport participation and prior concussion (0, 1+) on brain structure and baseline clinical variables. Athletes with prior concussion across both groups reported significantly more baseline concussion and psychological symptoms (allps < 0.05). The relationship between years of primary sport participation and thalamic volume differed between CS and NCS (p= 0.015), driven by a significant inverse association between primary years of participation and thalamic volume in CS (p= 0.007). Additional analyses limited to CS alone showed that the relationship between years of primary sport participation and dorsal striatal volume was moderated by concussion history (p= 0.042). Finally, CS with prior concussion had larger hippocampal volumes than CS without prior concussion (p= 0.015). Years of contact sport exposure and prior concussion(s) are associated with differences in subcortical volumes in young-adult, active collegiate athletes, consistent with prior literature in retired, primarily symptomatic contact sport athletes. Longitudinal follow-up studies in these athletes are needed to determine clinical significance of current findings.