eIF2-dependent translation initiation: Memory consolidation and disruption in Alzheimer's disease.
eIF2-dependent translation initiation: Memory consolidation and disruption in Alzheimer's disease.
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DOI：
10.1016/j.semcdb.2021.07.009
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发表时间：
2022-05
影响因子：
7.3
通讯作者：
Klann E
中科院分区：
文献类型：
--
作者：
Oliveira MM;Klann E
记忆储存是一种保守的生存能力特征，几乎存在于任何复杂的物种中。在过去的几十年里，人们投入了大量的精力来了解记忆是如何形成的，以及哪些分子开关定义了记忆是否应该储存较短或较长的时间。其中，已知从头蛋白质合成是短期记忆向长期记忆转换所必需的。突触可塑性和记忆巩固涉及许多翻译调控途径，其中包括真核起始因子2 α（eIF 2 α）的磷酸化，它已成为长时程记忆巩固的关键分子开关。在这篇综述中，我们讨论了有关的从头蛋白质合成记忆形成的要求，如何在神经元中调节局部树突和轴突的翻译，以及这些如何影响记忆巩固的研究结果。我们还强调了eIF 2 α依赖性翻译起始对突触可塑性和记忆形成的重要性。最后，我们将eIF 2 α的异常磷酸化如何促进阿尔茨海默病（AD）的病理学，以及如何预防eIF 2依赖性翻译的破坏可能是预防和/或恢复AD记忆丧失的治疗途径。
Memory storage is a conserved survivability feature, present in virtually any complex species . During the last few decades, much effort has been devoted to understanding how memories are formed and which molecular switches define whether a memory should be stored for a short or a long period of time. Among these, de novo protein synthesis is known to be required for the conversion of short- to long-term memory. There are a number translational control pathways involved in synaptic plasticity and memory consolidation, including the phosphorylation of the eukaryotic initiation factor 2 alpha (eIF2α), which has emerged as a critical molecular switch for long-term memory consolidation. In this review, we discuss findings pertaining to the requirement of de novo protein synthesis to memory formation, how local dendritic and axonal translation is regulated in neurons, and how these can influence memory consolidation. We also highlight the importance of eIF2α-dependent translation initiation to synaptic plasticity and memory formation. Finally, we contextualize how aberrant phosphorylation of eIF2α contributes to Alzheimer’s disease (AD) pathology and how preventing disruption of eIF2-dependent translation may be a therapeutic avenue for preventing and/or restoring memory loss in AD.
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影响因子：
7.7
作者：
Alvarez-Castelao, Beatriz;Dieck, Susanne Tom;Schuman, Erin M.
通讯作者：
Schuman, Erin M.
影响因子：
4.8
作者：
De Felice, Fernanda G.;Velasco, Pauline T.;Klein, William L.
通讯作者：
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影响因子：
64.8
作者：
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通讯作者：
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影响因子：
5.9
作者：
Elder MK;Erdjument-Bromage H;Oliveira MM;Mamcarz M;Neubert TA;Klann E
通讯作者：
Klann E
影响因子：
16.2
作者：
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通讯作者：
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