Ontogeny of myeloid cells.
Ontogeny of myeloid cells.
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DOI：
10.3389/fimmu.2014.00423
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发表时间：
2014
影响因子：
7.3
通讯作者：
Goriely S
中科院分区：
文献类型：
--
作者：
De Kleer I;Willems F;Lambrecht B;Goriely S
粒细胞、单核细胞、巨噬细胞和树突状细胞(DC)代表白细胞的一个亚群，统称为髓系细胞。在哺乳动物的胚胎发育期间，骨髓生成是以一种循序渐进的方式进行的，从卵黄囊开始，最后到达骨髓(BM)。在这个过程中，这些早期的单核细胞祖细胞定植于各种器官，如脑、肝、皮肤和肺，并分化为常驻巨噬细胞，将在一生中自我维持。DC不断地从骨髓前体细胞中补充，但也可以在炎症条件下来自单核细胞。在这篇综述中，我们总结了不同类型的髓系细胞，并讨论了对它们在小鼠和人类从胎儿到成年的早期起源和发育的新见解。我们特别关注单核细胞、巨噬细胞和树突状细胞在这些不同发育阶段的功能，以及可能驱动这些适应的内在和环境影响。
Granulocytes, monocytes, macrophages, and dendritic cells (DCs) represent a subgroup of leukocytes, collectively called myeloid cells. During the embryonic development of mammalians, myelopoiesis occurs in a stepwise fashion that begins in the yolk sac and ends up in the bone marrow (BM). During this process, these early monocyte progenitors colonize various organs such as the brain, liver, skin, and lungs and differentiate into resident macrophages that will self-maintain throughout life. DCs are constantly replenished from BM precursors but can also arise from monocytes in inflammatory conditions. In this review, we summarize the different types of myeloid cells and discuss new insights into their early origin and development in mice and humans from fetal to adult life. We specifically focus on the function of monocytes, macrophages, and DCs at these different developmental stages and on the intrinsic and environmental influences that may drive these adaptations.