Anodal cerebellar stimulation increases cortical activation: Evidence for cerebellar scaffolding of cortical processing.
Anodal cerebellar stimulation increases cortical activation: Evidence for cerebellar scaffolding of cortical processing.
复制标题
DOI：
10.1002/hbm.26166
复制
发表时间：
2023-03
影响因子：
4.8
通讯作者：
中科院分区：
文献类型：
--
作者：
虽然小脑有助于非运动任务的性能，具体的贡献结构仍然未知。一种可能性是，小脑允许皮层处理的卸载，使用内部模型在任务执行期间提供支持。在这里，我们使用经颅直流电刺激来调节小脑功能，并研究对皮质激活模式的影响。参与者（n = 74; 22.03 ± 3.44岁）在功能性磁共振成像扫描之前接受右侧小脑的阴极、阳极或假刺激，在此期间，他们完成了序列学习和工作记忆任务。我们预测阴极刺激会改善，阳极刺激会阻碍任务执行和皮层激活。在行为上，阳极刺激在后期序列学习期间对行为产生负面影响。在功能上，我们发现，阳极小脑刺激导致增加双边皮质激活，特别是在顶叶和额叶区域已知参与认知处理。这表明，如果小脑不能发挥最佳功能，就需要更多的皮质资源。虽然小脑有助于非运动任务的性能，具体的贡献结构仍然未知。一种可能性是，小脑允许皮层处理的卸载，使用内部模型在任务执行期间提供支持。在功能上，我们发现阳极小脑刺激会导致双侧皮质激活增加，特别是在已知参与认知处理的顶叶和额叶区域。这表明，如果小脑不能发挥最佳功能，就需要更多的皮质资源。
While the cerebellum contributes to nonmotor task performance, the specific contributions of the structure remain unknown. One possibility is that the cerebellum allows for the offloading of cortical processing, providing support during task performance, using internal models. Here we used transcranial direct current stimulation to modulate cerebellar function and investigate the impact on cortical activation patterns. Participants (n = 74; 22.03 ± 3.44 years) received either cathodal, anodal, or sham stimulation over the right cerebellum before a functional magnetic resonance imaging scan during which they completed a sequence learning and a working memory task. We predicted that cathodal stimulation would improve, and anodal stimulation would hinder task performance and cortical activation. Behaviorally, anodal stimulation negatively impacted behavior during late‐phase sequence learning. Functionally, we found that anodal cerebellar stimulation resulted in increased bilateral cortical activation, particularly in parietal and frontal regions known to be involved in cognitive processing. This suggests that if the cerebellum is not functioning optimally, there is a greater need for cortical resources. While the cerebellum contributes to nonmotor task performance, the specific contributions of the structure remain unknown. One possibility is that the cerebellum allows for the offloading of cortical processing, providing support during task performance, using internal models. Functionally, we found that anodal cerebellar stimulation resulted in increased bilateral cortical activation, particularly in parietal and frontal regions known to be involved in cognitive processing. This suggests that if the cerebellum is not functioning optimally, there is a greater need for cortical resources.