Targeting and uptake of multilayered particles to colorectal cancer cells
Targeting and uptake of multilayered particles to colorectal cancer cells
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DOI：
10.1002/adma.200600564
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发表时间：
2006-08-04
影响因子：
29.4
通讯作者：
Caruso, Frank
中科院分区：
文献类型：
--
作者：
Cortez, Christina;Tomaskovic-Crook, Eva;Caruso, Frank
通过逐层技术形成的核/壳颗粒和胶囊通过人源化 A33 单克隆抗体 (huA33 mAb) 进行生物功能化，该抗体与结直肠癌细胞上存在的 A33 抗原结合（见图）。靶向结直肠癌细胞系显示出颗粒的选择性结合和内化。
Core/shell particles and capsules formed by a layer-by-layer technique are biofunctionalized with a humanized A33 monoclonal antibody (huA33 mAb) that binds to the A33 antigen present on colorectal cancer cells (see figure). Targeting to a colorectal cancer cell line shows selective binding and internalization of particles.