PROTON RADIOGRAPHY AS A TOOL FOR QUALITY-CONTROL IN PROTON THERAPY
PROTON RADIOGRAPHY AS A TOOL FOR QUALITY-CONTROL IN PROTON THERAPY
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DOI：
10.1118/1.597470
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发表时间：
1995-04-01
期刊：
影响因子：
3.8
通讯作者：
PEDRONI, E
中科院分区：
文献类型：
--
作者：
SCHNEIDER, U;PEDRONI, E
质子射线照相术是质子治疗的质量控制工具。产生的图像与范围和范围的不确定性信息的质子通过幻影（奥尔德森幻影和羊的头）。利用距离图像，可以验证患者相对于射束的正确定位。距离不确定性图像用于定量检测质子通过患者体内不均匀性的距离变化。这些测量可用于指示质子治疗期间的危急情况或确定肿瘤体积周围的安全裕度。利用范围信息，确定了用于质子治疗计划的计算机断层扫描Hounsfield值与相对质子阻止本领的不同校准的精度。发现通过对从组织替代物测量获得的校准数据进行详细分析，可以将范围内的精度提高2.5倍。由此产生的范围误差在定位精度（± 1 mm）的量级。
Proton radiography is investigated for its use as a quality control tool in proton therapy. Images were produced both with range and range uncertainty information of protons passing through phantoms (Alderson phantom and a sheep's head). With the range images the correct positioning of the patient with respect to the beam could be verified. The range uncertainty images were used to quantitatively detect range variations of protons passing through inhomogeneities in the patient. These measurements can be used to indicate critical situations during proton therapy or to determine the safety margin around the tumor volume. With the range information the precision of different calibrations of computer tomography Hounsfield values to relative proton stopping power, used for proton treatment planning, was determined. It is found that the precision in range can be improved by a detailed analysis of the calibration data obtained from tissue‐substitute measurements, by a factor of 2.5. The resulting range errors are in the order of the positioning precision (∼1 mm).