Emerging therapies for the treatment of hepatitis C.

Emerging therapies for the treatment of hepatitis C.
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DOI:
10.1002/emmm.201303131
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发表时间:
2014-01
影响因子:
11.1
通讯作者:
Zeuzem S
Zeuzem S
中科院分区:
医学1区
文献类型:
--
作者:
Lange CM;Jacobson IM;Rice CM;Zeuzem S

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治疗丙型肝炎病毒(HCV)感染的机会正在迅速发展。从1992年引入干扰素-α单药治疗到2011年批准基于替拉瑞韦和boceprevir的聚乙二醇化干扰素-α和利巴韦林三联疗法,治愈HCV基因型1感染患者的机会从<10%提高到约70%。显著的进一步改善即将出现,这可能在不久的将来用全口服、无干扰素的方案治愈几乎所有丙型肝炎患者。本文对这些令人兴奋的发展进行了综述。
Opportunities to treat infection with hepatitis C virus (HCV) are evolving rapidly. From the introduction of interferon-α monotherapy in 1992 to the approval of telaprevir- and boceprevir-based triple therapies with pegylated interferon-α and ribavirin in 2011, the chances of curing patients infected with HCV genotype 1 have improved from <10% to approximately 70%. Significant further improvements are on the horizon, which may well cure virtually all hepatitis C patients with an all-oral, interferon-free regimen in the very near future. These exciting developments are reviewed in the present article.
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