Expression of Blood Cells Associated CD Markers and Cardiovascular Diseases: Clinical Applications in Prognosis
Expression of Blood Cells Associated CD Markers and Cardiovascular Diseases: Clinical Applications in Prognosis
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DOI：
10.1093/labmed/lmz049
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发表时间：
2020-03-01
影响因子：
1.3
通讯作者：
Saki, Najmaldin
中科院分区：
文献类型：
--
作者：
Haybar, Habib;Behzad, Masumeh Maleki;Saki, Najmaldin
背景：心血管疾病（CVD）是全球死亡的主要原因。各种研究结果表明，血细胞的频率和功能异常可能与CVD并发症有关。在这篇综述中，我们主要关注CD表达的异常，（分化簇）标志物来评估这些异常与CVD预后的关联。我们通过PubMed检索确定了相关文献（1990-2018）使用术语“心血管疾病”、“CD标记物”、“白细胞”、“血小板”和“内皮细胞”的英文文章。CD标记物表达对心血管疾病预后的影响有多种机制，从促炎过程到血细胞功能障碍。考虑到CD标记物表达对心血管疾病预后的可能影响，特别是急性心肌梗死和动脉粥样硬化的预后，需要在大队列中进行长期研究，以确定CD标志物的预后价值，并使用适当的治疗药物靶向它们。
Background: Cardiovascular diseases (CVDs) are a major cause of mortality worldwide. The results of various studies have shown that abnormality in the frequency and function of blood cells can be involved in CVD complications. In this review, we have focused on abnormalities in the expression of the CD (cluster of differentiation) markers of blood cells to assess the association of these abnormalities with CVD prognosis.Methods: We identified the relevant literature through a PubMed search (1990-2018) of English-language articles using the terms "Cardiovascular diseases", "CD markers", "leukocytes", 'platelets", and "endothelial cells".Results: There is a variety of mechanisms for the effect of CD-marker expressions on CVDs prognosis, ranging from proinflammatory processes to dysfunctional effects in blood cells.Conclusion: Considering the possible effects of CD-marker expression on CVDs prognosis, particularly prognosis of acute myocardial infarction and atherosclerosis, long-term studies in large cohorts are required to identify the prognostic value of CD markers and to target them with appropriate therapeutic agents.