Association of CTLA-4 polymorphisms with increased risks of myasthenia gravis
Association of CTLA-4 polymorphisms with increased risks of myasthenia gravis
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CTLA-4 多态性与重症肌无力风险增加的关联
DOI：
10.1111/ahg.12262
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发表时间：
2018-11-01
影响因子：
1.9
通讯作者：
Wu, Xiushan
中科院分区：
文献类型：
--
作者：
Li, Fang;Yuan, Wuzhou;Wu, Xiushan
重症肌无力(MG)被认为是一种自身免疫性疾病，由抗烟碱型乙酰胆碱受体的自身抗体引起的神经肌肉传递功能障碍引起。大量研究证实细胞毒性T淋巴细胞相关抗原-4(CTLA-4)是MG的候选基因。最近的一些报道表明，CTLA-4的单核苷酸多态(SNPs)，包括rs733618、rs4553808、rs5742909、rs231775和rs3087243与MG的风险相关；然而，结果并不一致。为了评估CTLA-4 SNPs与MG易感性的相关性，在一系列数据库搜索之后进行了Meta分析。共有来自12项研究的1460名病例和1652名对照参加了分析。我们的结果表明rs231775和rs733618与MG的高风险相关，为今后的病例对照研究提供了潜在的参考。
Myasthenia gravis (MG) is considered to be a kind of autoimmune disorder resulting from dysfunction of neuromuscular transmission caused by autoantibodies against the nicotinic acetylcholine receptors. A number of studies have identified Cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) as a candidate gene for MG. Several recent reports have indicated that single nucleotide polymorphisms (SNPs) of CTLA-4, including rs733618, rs4553808, rs5742909, rs231775, and rs3087243 were associated with the risks of MG; however, the results were not consistent. To assess the correlations between CTLA-4 SNPs and MG susceptibility, a meta-analysis was performed following a series of database searching. A total of 1460 cases and 1652 controls from 12 studies were enrolled in the analysis. Our results indicated that rs231775 and rs733618 were associated with higher risks of MG, providing potential references for future case-control studies.