Oral "hairy" leucoplakia in male homosexuals: evidence of association with both papillomavirus and a herpes-group virus.
Oral "hairy" leucoplakia in male homosexuals: evidence of association with both papillomavirus and a herpes-group virus.
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男性同性恋者口腔“毛状”白斑：与乳头瘤病毒和疱疹病毒相关的证据。
DOI：
10.1016/s0140-6736(84)90872-9
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
deSouza,Y
中科院分区：
文献类型：
--
作者：
Greenspan,D;Greenspan,JS;Conant,M;Petersen,V;SilvermanJr,S;deSouza,Y
据报道，在旧金山弗朗西斯科地区的男性同性恋者中爆发了一种新的口腔白斑病，主要发生在舌头的侧缘。许多患者表现出免疫抑制的证据，并且在病变中经常发现念珠菌。其组织学特征与皮肤扁平疣相似。有乳头瘤病毒核心抗原的免疫细胞化学证据在77%的30个活检标本，但没有乳头瘤病毒检测到的样品中，从6个随机选择的患者通过电子显微镜。在这6例患者中有5例有疱疹病毒的证据。卡氏肺孢子虫已在33个月的37例患者中的8例发展。白斑可能预示艾滋病，可能与乳头瘤病毒和疱疹病毒有关，并可能为其他形式的口腔上皮增生和发育不良的发病机制提供线索。
An outbreak of a new form of oral leucoplakia, found principally on the lateral borders of the tongue, is reported in male homosexuals in the San Francisco area. Many of the patients showed evidence of immunosuppression, and candida was often found in the lesions. The characteristic histology is similar to that of the flat wart of skin. There was immunocytochemical evidence of papillomavirus core antigen in 77% of 30 biopsy specimens, but no papillomaviruses were detected by electron microscopy in samples from 6 randomly selected patients. In 5 of these 6 patients there was evidence of a herpes-type virus.Pneumocystis cariniipneumonia has developed in 8 of 37 patients in a 33-month period. This leucoplakia may presage AIDS, may be associated with both papillomavirus and a herpes-type virus, and may offer clues to the pathogenesis of other forms of oral epithelial hyperplasia and dysplasia.