Associations between estrogen receptor genetic polymorphisms, smoking status, and prostate cancer risk: a case-control study in Japanese men
Associations between estrogen receptor genetic polymorphisms, smoking status, and prostate cancer risk: a case-control study in Japanese men
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DOI：
10.1007/s12199-015-0471-5
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发表时间：
2015-09-01
影响因子：
4.7
通讯作者：
Katoh, Takahiko
中科院分区：
文献类型：
--
作者：
Lu, Xi;Yamano, Yuko;Katoh, Takahiko
前列腺癌（PCa）是男性死亡的主要原因之一。本研究通过对750例日本前列腺癌患者和870例健康对照者进行病例对照研究，探讨ESR 1和ESR 2基因型与吸烟状态相关的PCa易感性的关系。在病例对照组中进行年龄匹配后，352名对照和352名病例被纳入本研究。采用Logistic回归分析方法，对ESR 1和ESR 2基因型进行病例/对照分析，ESR 2 rs 4986938 AG和AG + AA基因型与PCa发病风险显著降低相关AG：OR = 0.68，95%CI 0.47-0.97，P < 0.05; AG + AA：OR = 0.67，95%CI 0.47-0.94，P < 0.05）。然而，ESR 1 rs 2234693与PCa风险之间没有显著相关性。当患者根据吸烟状态分组时，ESR 2 rs 1256049 AA基因型（OR = 0.48，95%CI 0.25-0.95，P < 0.05）和ESR 2 rs 4986938 AG + AA基因型（OR = 0.64，95% CI 0.41-1.00，P < 0.05）显示，在所有年龄组中，提示雌激素受体ESR 2对前列腺癌的预测具有重要作用，不同的SNPs对前列腺癌的预测价值不同。吸烟可能影响雌激素活性，并可能影响前列腺癌与雌激素受体。
Prostate cancer (PCa) is one of the major causes of death among men. Our study investigated the association of ESR1 and ESR2 genotypes with susceptibility to PCa in relation to smoking status in Japanese.A case-control study was performed with 750 Japanese prostate cancer patients and 870 healthy controls. After age-matching in case-controls, 352 controls and 352 cases were enrolled in this study. By using logistic regression analysis, the different genotypes from ESR1 and ESR2 were analyzed according to case/control status.ESR2 rs4986938 AG and AG + AA genotypes were associated with significantly decreased risk of PCa (AG: OR = 0.68, 95 % CI 0.47-0.97, P < 0.05 and AG + AA: OR = 0.67, 95 % CI 0.47-0.94, P < 0.05). However, there was no significant association between ESR1 rs2234693 and PCa risk. When patients were grouped according to smoking status, the ESR2 rs1256049 AA genotype (OR = 0.48, 95 % CI 0.25-0.95, P < 0.05) and ESR2 rs4986938 AG + AA genotype (OR = 0.64, 95 % CI 0.41-1.00, P < 0.05) showed significantly decreased PCa risk in the ever-smoker group.Our results suggest that the estrogen receptor ESR2 has a very important function to predict PCa and that different SNPs have different predictive values. Smoking may influence estrogenic activity and may influence PCa together with the estrogen receptor.