The effects of trichlorfon on maternal reproduction and mouse embryo development during organogenesis.
The effects of trichlorfon on maternal reproduction and mouse embryo development during organogenesis.
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DOI：
10.2486/indhealth.47.313
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发表时间：
2009-07
影响因子：
2
通讯作者：
Ying Tian;Fei Dai;Li Shen;Yi Feng;Yu Gao;Lei Xu;Song Han;Xiao-ming Shen
中科院分区：
文献类型：
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作者：
Ying Tian;Fei Dai;Li Shen;Yi Feng;Yu Gao;Lei Xu;Song Han;Xiao-ming Shen
有机磷农药敌百虫是一种广泛使用的农用广谱杀虫剂。母亲摄入受污染食物中的低水平敌百虫对发育中胎儿的健康影响尚不清楚。我们评估了妊娠雌性小鼠在器官形成期间（妊娠第6-15天）灌胃暴露于蒸馏水或低水平（12.5、25或50 mg/kg体重/d）敌百虫后的生殖和发育毒性。在第17天处死后，评估生殖结局和致畸作用。敌百虫暴露不会影响母体体重增加、器官重量、黄体、着床部位或生殖成功率，也不会影响明显的外部或骨骼异常。敌百虫对上述任何体内生殖和胎儿终点均无影响，这表明敌百虫的生殖毒性低于50毫克/千克体重/天时可能不会产生危害。然而，有必要开展一项精心设计的流行病学研究，以进一步评估人类发育中的胎儿接触较低水平敌百虫的风险。
The organophosphate pesticide trichlorfon is a widely used agricultural broad spectrum insecticide. The health effects on a developing fetus of low level exposure to trichlorofon ingested by the mother in contaminated foods are unclear. We assessed reproductive and developmental toxicity in pregnant female mice following gavage-administered exposure to distilled water or to low levels (12.5, 25, or 50 mg/kg body weight/d) of trichlorofon during organogenesis (gestation days 6-15). Following sacrifice on day 17, reproductive outcomes and teratogenesis were assessed. Trichlorfon exposure did not affect maternal weight gain, organ weights, corpora lutea, implantation sites, or reproductive success, nor where external or skeletal abnormalities evident. The lack of effects of trichlorfon on any in vivo reproductive and fetuses endpoints above suggested that for trichlorfon, a hazard of reproductive toxicity below 50 mg/kg body weight/d maybe not expected. However, a well-designed epidemiological study is necessary for further risk assessment of human developing fetus exposed to trichlorfon at a lower level.