MAIN EXCRETION METABOLITES OF 7-METHOXY-2-NITRONAPHTHO[2,1-B]FURAN (R-7000) IN RATS
MAIN EXCRETION METABOLITES OF 7-METHOXY-2-NITRONAPHTHO[2,1-B]FURAN (R-7000) IN RATS
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DOI：
10.3109/00498258609043553
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发表时间：
1986-07-01
期刊：
影响因子：
1.8
通讯作者：
CHABARD, JL
中科院分区：
文献类型：
--
作者：
MAURIZIS, JC;MADELMONT, JC;CHABARD, JL
从大鼠胆汁和尿液中分离到的主要代谢物，经7-甲氧基-2-硝基-2-硝基并[2，1-b]呋喃(R7000；MNNF)单次给药后，通过与人工合成的正品参比化合物的色谱行为和质谱图的比较，鉴定了它们的主要代谢物。对代谢产物的分析表明，该化合物在体内有三条代谢途径，即甲氧基的脱甲基化、芳环的羟基化和呋喃环的裂解，然后硝基还原为胺。
Major metabolites, isolated from rat bile and urine after administration of a single dose of 7-methoxy-2-nitronaphtho[2,1-b]furan (R 7000; MNNF) labelled with 14C on the furan ring and on the methoxy group, were identified by comparison of their chromatographic behaviour and mass spectra with synthetic authentic reference compounds. Analysis of metabolites indicated three metabolic pathways for this compound in vivo, namely, demethylation of the methoxy group, hydroxylation of the aromatic ring and cleavage of the furan ring, followed by the reduction of the nitro group to amine.