Dengue viruses cluster antigenically but not as discrete serotypes.
Dengue viruses cluster antigenically but not as discrete serotypes.
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DOI：
10.1126/science.aac5017
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发表时间：
2015-09-18
期刊：
影响因子：
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通讯作者：
Smith DJ
中科院分区：
文献类型：
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作者：
Katzelnick LC;Fonville JM;Gromowski GD;Bustos Arriaga J;Green A;James SL;Lau L;Montoya M;Wang C;VanBlargan LA;Russell CA;Thu HM;Pierson TC;Buchy P;Aaskov JG;Muñoz-Jordán JL;Vasilakis N;Gibbons RV;Tesh RB;Osterhaus AD;Fouchier RA;Durbin A;Simmons CP;Holmes EC;Harris E;Whitehead SS;Smith DJ
四种遗传上不同的登革病毒（DENV）类型传统上被归类为血清型。DENV类型之间的抗原和遗传差异影响疾病结果、疫苗诱导的保护、流行程度和病毒进化。我们通过从非洲绿色猴以及人类疫苗接种和自然感染后获得的中和抗体滴度构建的抗原图谱来表征DENV类型的抗原多样性。在遗传、地理和时间上，不同的DENV分离株按类型松散地聚集，但我们发现许多分离株与不同类型的病毒在抗原性上与相同类型的一些病毒相似。初次感染抗血清中和相同DENV类型的所有病毒的效果并不比其他类型的病毒好，直到感染后两年，并且对同源型分离株的中和效果也没有改善。典型的DENV类型在抗原上不是同质的，这对疫苗接种和免疫动力学、疾病和DENV进化的研究具有意义。
The four genetically divergent dengue virus (DENV) types are traditionally classified as serotypes. Antigenic and genetic differences among the DENV types influence disease outcome, vaccine-induced protection, epidemic magnitude, and viral evolution. We characterized antigenic diversity in the DENV types by antigenic maps constructed from neutralizing antibody titers obtained from African green monkeys and after human vaccination and natural infections. Genetically, geographically, and temporally, diverse DENV isolates clustered loosely by type, but we found many are as similar antigenically to a virus of a different type as to some viruses of the same type. Primary infection antisera did not neutralize all viruses of the same DENV type any better than other types did up to two years after infection and did not show improved neutralization to homologous type isolates. That the canonical DENV types are not antigenically homogenous has implications for vaccination and research on the dynamics of immunity, disease, and the evolution of DENV.