The effects of refractory epilepsy on intellectual functioning in children and adults.: A longitudinal study
The effects of refractory epilepsy on intellectual functioning in children and adults.: A longitudinal study
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DOI：
10.1053/seiz.2000.0503
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发表时间：
2001-06-01
影响因子：
3
通讯作者：
Loyning, Y
中科院分区：
文献类型：
--
作者：
Bjornæs, H;Stabell, K;Loyning, Y
本研究的目的是比较难治性癫痫发作对儿童和成人患者智力功能的长期影响，同时考虑到癫痫的严重程度。对34例患者，17名儿童(平均年龄10.2岁)和17名成年人(平均年龄24.4岁)进行了两次韦氏智力量表测试。两组的平均重测间隔分别为3.5年和6.0年。根据对癫痫发作严重程度、发作间期脑电病理和每个患者接受的抗癫痫药物数量的回顾评估，在试验1中，两组之间的癫痫严重程度没有统计学上的显著差异。在重测期间，对这些变量变化的评估没有显示两组患者的不同病程。尽管有这些相似之处，但在智力功能变化方面，儿童和成人之间存在统计上的显著差异。在儿童组中，在重测期间，平均智商(IQ)分数下降，而成人组的智商分数上升。结论是，反复发作可能是儿童智力下降的一个相当大的风险，而早期癫痫发作的成年人的智力功能似乎不那么脆弱。(C)2001东亚银行贸易有限公司。
The aim of this study was to compare the long-term consequences of refractory epileptic seizures for intellectual functioning in pediatric and adult patients, taking the severity of the epilepsy into consideration. Thirty-four patients, 17 children (mean age 10.2 years) and 17 adults (mean age 24.4 years) were tested twice with the age-appropriate version of Wechsler's Intelligence Scales. The mean test-retest interval in the two,groups was 3.5 and 6.0 years, respectively. There were no statistically significant differences between the,groups with respect to severity of the epilepsy at Test 1, as indicated by retrospective assessments of seizure severity, interictal EEG pathology, and number of antiepileptic drugs received per patient. Assessments of changes in these variables during the test-retest interval did not indicate different courses of the disease in the two groups. Despite these similarities, a statistically significant difference was found between the children and the adults regarding changes in intellectual functioning. In the children, there was a decline in mean intelligence quotient (IQ) scores during the test-retest interval, while the IQ scores increased in the adult group. It is concluded that recurrent seizures may represent a considerable risk for intellectual decline in children, while intellectual functioning seem to be less vulnerable in adults with early onset of epilepsy. (C) 2001 BEA Trading Ltd.