Action potential‐triggered somatic exocytosis in mesencephalic trigeminal nucleus neurons in rat brain slices
Action potential‐triggered somatic exocytosis in mesencephalic trigeminal nucleus neurons in rat brain slices
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DOI：
10.1113/jphysiol.2011.221051
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发表时间：
2012-02
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影响因子：
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通讯作者：
Bo Zhang;Xiaoyu Zhang;P. Luo;Wei Huang;Feipeng Zhu;Tao Liu;Yi-Ru Du;Qihui Wu;Jing Lü;Yun Xiu;Lina Liu;Hong-ping Huang;Shu Guo;Hui Zheng;C. Zhang;Zhuan Zhou
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文献类型：
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作者：
Bo Zhang;Xiaoyu Zhang;P. Luo;Wei Huang;Feipeng Zhu;Tao Liu;Yi-Ru Du;Qihui Wu;Jing Lü;Yun Xiu;Lina Liu;Hong-ping Huang;Shu Guo;Hui Zheng;C. Zhang;Zhuan Zhou
非技术总结Ca 2+调节的轴突终末胞吐作用对于CNS中的神经元通讯至关重要。此外，胞体也可能在脑中的一些神经元中经历Ca 2+依赖性胞吐。在本工作中，我们记录了中脑三叉神经核（MeV）胞体的活性/Ca 2+依赖性分泌。在神经活动之后，躯体分泌信号被记录为膜表面积的变化，如通过膜电容测量的。去极化诱导的体细胞胞吐与GABA介导的突触后电流的短暂减少相关。这些结果表明，躯体分泌物可能在感觉MeV脑片神经元中连接前和连接后神经元之间的双向通信中发挥作用。
Non‐technical summary Ca2+‐regulated axon terminal exocytosis is essential for neuronal communication in the CNS. Besides, the somata may also undergo Ca2+‐dependent exocytosis in some neurons in the brain. In the present work we recorded activity/Ca2+‐dependent secretion in somata of the mesencephalic trigeminal nucleus (MeV). Following nerve activity, somatic secretion signals are recorded as changes in membrane surface area, as measured by the membrane capacitance. The depolarization‐induced somatic exocytosis correlates with transient reduction in the GABA‐mediated postsynaptic currents. These results implicated that the somatic secretion may play a role in bidirectional communication between pre‐ and post‐connected neurons in the sensory MeV brain slice neurons.